Indolin-6-amine

Base Information

• Chemical Name: Indolin-6-amine
• CAS No.: 15918-79-3
• Molecular Formula: C8H10N2
• Molecular Weight: 134.181
• Mol file: 15918-79-3.mol

Synonyms:(2,3-dihydro-1H-indol-6-yl)amine;(2,3-dihydro-1H-inden-5-yl)isothiocyanate;indan-5-yl isothiocyanate;indolin-6-ylamine;6-aminoindoline;5-Indanyl Isothiocyanate;

Chemical Property of Indolin-6-amine

Chemical Property:

• Boiling Point: 304.1±31.0 °C(Predicted)
• PKA: 5.71±0.20(Predicted)
• PSA: 38.05000
• Density: 1.148±0.06 g/cm3(Predicted)
• LogP: 1.95600

Purity/Quality:

97% ^*data from raw suppliers

Indolin-6-amine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Indolin-6-amine

There total 4 articles about Indolin-6-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

6-nitroindoline (19727-83-4) → indolin-6-amine (15918-79-3)

Guidance literature:

With hydrogen; In methanol; ethyl acetate; at 90 ℃; for 0.333333h; chemoselective reaction; Flow reactor; Green chemistry;

DOI:10.1039/C8NJ04646H

Reference yield: 93.0%

6-amino-2,3-dihydroindole-1-carboxylic acid tert-butyl ester (129488-00-2) → indolin-6-amine (15918-79-3)

Guidance literature:

In acetonitrile; at 300 ℃; under 75007.5 Torr;

DOI:10.1021/acs.orglett.6b00378

Reference yield: 40.0%

6-amino-1H-indole (5318-27-4) → indolin-6-amine (15918-79-3)

Guidance literature:

With sodium cyanoborohydride; acetic acid; at 0 - 20 ℃; for 4.5h;

DOI:10.1021/acs.orglett.0c02128

upstream raw materials:

6-nitroindoline

1-indoline

6-amino-2,3-dihydroindole-1-carboxylic acid tert-butyl ester

6-amino-1H-indole

Downstream raw materials:

trans-N-(1-Benzyl-piperidin-4-yl)-N-(2,3-dihydro-1H-indol-6-yl)-3-phenyl-acrylamide

1-methyl-2,3-dihydro-indol-6-ol

6-hydroxy-indoline

C₂₉H₃₃N₃O₃