2-((1-METHYLPYRROLIDIN-2-YL)METHYL)ISOINDOLINE DIHYDROCHLORIDE

Base Information

Chemical Name:2-((1-METHYLPYRROLIDIN-2-YL)METHYL)ISOINDOLINE DIHYDROCHLORIDE
CAS No.:159497-37-7
Molecular Formula:C₁₄H₂₀N₂
Molecular Weight:216.326
Hs Code.:
Mol file:159497-37-7.mol

Synonyms:

Suppliers and Price of 2-((1-METHYLPYRROLIDIN-2-YL)METHYL)ISOINDOLINE DIHYDROCHLORIDE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of 2-((1-METHYLPYRROLIDIN-2-YL)METHYL)ISOINDOLINE DIHYDROCHLORIDE

Chemical Property:

Melting Point:167-169 °C
Boiling Point:295.3±20.0 °C(Predicted)
PKA:10.05±0.40(Predicted)
PSA：6.48000
Density:1.065±0.06 g/cm3(Predicted)
LogP:3.57620

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-((1-METHYLPYRROLIDIN-2-YL)METHYL)ISOINDOLINE DIHYDROCHLORIDE

There total 5 articles about 2-((1-METHYLPYRROLIDIN-2-YL)METHYL)ISOINDOLINE DIHYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: tert-butyl (S)-2-(isoindoline-2-carbonyl)pyrrolidine-1-carboxylate

: 159497-37-7
(S)-1-methyl-2-[(dihydroisoindol-2-yl)methyl]pyrrolidine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; Heating;
DOI:10.1021/jo962090p

Reference yield:

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 159497-37-7
(S)-1-methyl-2-[(dihydroisoindol-2-yl)methyl]pyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: 58 percent / DCC / CH₂Cl₂ / 48 h / Ambient temperature

2: 98 percent / LiAlH₄ / tetrahydrofuran / Heating

With lithium aluminium tetrahydride; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo962090p

Reference yield:

: 147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7
L-proline

: 159497-37-7
(S)-1-methyl-2-[(dihydroisoindol-2-yl)methyl]pyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / tetrahydrofuran / 17 h / 0 °C

2.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0.5 h / -20 °C

2.2: 16 h / -20 - 25 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 24 h / Reflux

With 4-methyl-morpholine; lithium aluminium tetrahydride; sodium hydrogencarbonate; isobutyl chloroformate; In tetrahydrofuran;
DOI:10.1021/acs.orglett.7b03351