3-Chloro-N,N-diethylbenzaMide, 97%

Base Information

• Chemical Name: 3-Chloro-N,N-diethylbenzaMide, 97%
• CAS No.: 15952-65-5
• Molecular Formula: C11H14ClNO
• Molecular Weight: 211.691
• Mol file: 15952-65-5.mol

Synonyms:N,N-diethyl-m-chlorobenzamide;3-Chlor-benzoesaeure-N,N-diethylamid;3-chlor-2-deutero-N,N-diethylbenzamide;N,N-diethyl-3-chlorobenzamide;meta-chlor-N,N-diethylbenzamide;HMS1537M18;benzamide,3-chloro-N,N-diethyl;

Chemical Property of 3-Chloro-N,N-diethylbenzaMide, 97%

Chemical Property:

• Boiling Point: 96-97 °C(Press: 0.2 Torr)
• PKA: -1.87±0.70(Predicted)
• PSA: 20.31000
• Density: 1.115±0.06 g/cm3(Predicted)
• LogP: 2.82200

Purity/Quality:

99% ^*data from raw suppliers

3-Chloro-N,N-diethylbenzamide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Chloro-N,N-diethylbenzaMide, 97%

There total 6 articles about 3-Chloro-N,N-diethylbenzaMide, 97% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

N-formyldiethylamine (617-84-5) + m-Chlorobenzoyl chloride (618-46-2) → N,N-diethyl-m-chlorobenzamide (15952-65-5)

Guidance literature:

With dysprosium; at 20 ℃; for 0.333333h; Inert atmosphere;

DOI:10.1021/om200080f

Reference yield: 87.0%

disulfiram (97-77-8) + 3-chlorobenzoate (535-80-8) → N,N-diethyl-m-chlorobenzamide (15952-65-5)

Guidance literature:

With di-tert-butyl peroxide; copper(I) bromide; In ethyl acetate; at 120 ℃;

DOI:10.1080/00397911.2017.1330960

Reference yield: 70.0%

m-Chlorobenzoyl chloride (618-46-2) + triethylamine (121-44-8) → N,N-diethyl-m-chlorobenzamide (15952-65-5)

Guidance literature:

With titanium tetrachloride; In dichloromethane; at 20 ℃; for 12h; Sealed tube; Inert atmosphere;

DOI:10.1039/c8ob01536h

upstream raw materials:

N-formyldiethylamine

m-Chlorobenzoyl chloride

2-(diethylamino)-2-oxoacetic acid

disulfiram

Downstream raw materials:

N,N-diethyl-3-chloro-2-(trimethylsilyl)benzamide

3-chloro-2-((trimethylsilyl)methyl)benzaldehyde

3-Chloro-N,N-diethyl-2-sulfamoyl-benzamide

N,N-diethyl-3-chloro-2-<(trimethylsilyl)methyl>benzamide

Refernces

• 1、 Zeng, Meng-Tian,Xu, Wan,Liu, Min,Liu, Xing,Chang, Cai-Zhu,Zhu, Hui,Dong, Zhi-Bing. "Copper-catalyzed amidation of benzoic acids using tetraalkylthiuram disulfides as amine sources". supporting information. p. 1434 - 1440. Retrieved 2017/08/16.
• 2、 Li, Mingzong,Wang, Cong,Fang, Ping,Ge, Haibo. "Pd(ii)-catalyzed decarboxylative cross-coupling of oxamic acids with potassium phenyltrifluoroborates under mild conditions". supporting information; experimental part. p. 6587 - 6589. Retrieved 2011/06/25.