[1,1'-Biphenyl]-2-sulfonamide, 4'-[[3-butyl-1-(2-chloro-5-nitrophenyl)-1,5-dihydro-5-oxo-4H-1,2,4-triazol -4-yl]methyl]-3'-fluoro-

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Chemical Name:[1,1'-Biphenyl]-2-sulfonamide, 4'-[[3-butyl-1-(2-chloro-5-nitrophenyl)-1,5-dihydro-5-oxo-4H-1,2,4-triazol -4-yl]methyl]-3'-fluoro-
CAS No.:159547-39-4
Molecular Formula:C25H23ClFN5O5S
Molecular Weight:560.006
Hs Code.:
Mol file:159547-39-4.mol

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Chemical Property of [1,1'-Biphenyl]-2-sulfonamide, 4'-[[3-butyl-1-(2-chloro-5-nitrophenyl)-1,5-dihydro-5-oxo-4H-1,2,4-triazol -4-yl]methyl]-3'-fluoro-

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Technology Process of [1,1'-Biphenyl]-2-sulfonamide, 4'-[[3-butyl-1-(2-chloro-5-nitrophenyl)-1,5-dihydro-5-oxo-4H-1,2,4-triazol -4-yl]methyl]-3'-fluoro-

There total 10 articles about [1,1'-Biphenyl]-2-sulfonamide, 4'-[[3-butyl-1-(2-chloro-5-nitrophenyl)-1,5-dihydro-5-oxo-4H-1,2,4-triazol -4-yl]methyl]-3'-fluoro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 159547-39-4
5-n-butyl-2-(2-chloro-5-nitrophenyl)-2,4-dihydro-4-<(3-fluoro-2'-sulfamoylbiphenyl-4-yl)methyl>-3H-1,2,4-triazol-3-one

Guidance literature:

Reference yield: 72.0%

: 159547-31-6
5-n-butyl-4-<<2'-(N-tert-butylsulfamoyl)-3-fluorobiphenyl-4-yl>methyl>-2-(2-chloro-5-nitrophenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

: 159547-39-4
5-n-butyl-2-(2-chloro-5-nitrophenyl)-2,4-dihydro-4-<(3-fluoro-2'-sulfamoylbiphenyl-4-yl)methyl>-3H-1,2,4-triazol-3-one

Guidance literature:: With methoxybenzene; trifluoroacetic acid; Ambient temperature;
DOI:10.1021/jm00019a004

Reference yield:

: 5133-68-6
ethyl N-carbethoxyvalerimidate

: 159547-39-4
5-n-butyl-2-(2-chloro-5-nitrophenyl)-2,4-dihydro-4-<(3-fluoro-2'-sulfamoylbiphenyl-4-yl)methyl>-3H-1,2,4-triazol-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: 2.) Et₃N / 1.) toluene, 65 deg C, 4 h, 2.) toluene, 90 deg C, 16 h

2: 1.) NaH / 1.) DMF, 50 deg C, 3 h, 2.) DMF, 90 deg C, overnight

3: 52 percent / 1.25 N aq. NaOH, tetrakis(triphenylphosphine)palladium⁽⁰⁾ / toluene; ethanol / 4 h / 90 °C

4: 72 percent / TFA, anisole / Ambient temperature

With sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; methoxybenzene; triethylamine; trifluoroacetic acid; In ethanol; toluene;
DOI:10.1021/jm00019a004