PYRIDAZINE-3,4-DICARBOXYLIC ACID DIETHYL ESTER

Base Information

• Chemical Name: PYRIDAZINE-3,4-DICARBOXYLIC ACID DIETHYL ESTER
• CAS No.: 16082-13-6
• Molecular Formula: C10H12N2O4
• Molecular Weight: 224.216
• Hs Code.: 2933990090
• Mol file: 16082-13-6.mol

Synonyms:

Chemical Property of PYRIDAZINE-3,4-DICARBOXYLIC ACID DIETHYL ESTER

Chemical Property:

• PSA: 78.38000
• LogP: 0.83000
• Storage Temp.: 2-8°C

Purity/Quality:

NLT 98% ^*data from raw suppliers

Pyridazine-3,4-dicarboxylicaciddiethylester 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of PYRIDAZINE-3,4-DICARBOXYLIC ACID DIETHYL ESTER

There total 5 articles about PYRIDAZINE-3,4-DICARBOXYLIC ACID DIETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

6-ethoxy-3,4-diethoxycarbonyl-1-methoxycarbonyl-1,4,5,6-tetrahydropyridazine (129116-95-6,129116-99-0) → pyridazine-3,4-dicarboxylic acid diethyl ester (16082-13-6)

Guidance literature:

With bromine; acetic acid; at 23 ℃; for 23h;

Reference yield:

diethyl 2-(methoxycarbonylhydrazinylidene)butanedioate (129116-94-5) → pyridazine-3,4-dicarboxylic acid diethyl ester (16082-13-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 98 percent / sulfonyl chloride / 1,2-dichloro-ethane / 1 h / 20 - 31 °C

2: 82 percent / triethylamine / 1,2-dichloro-ethane / 19 h

3: 100 percent / bromine, acetic acid / 23 h / 23 °C

With sulfuryl dichloride; bromine; acetic acid; triethylamine; In 1,2-dichloro-ethane;

Reference yield:

diethyl 3-chloro-2-(methoxycarbonylhydrazinylidene)butanedioate (129116-93-4) → pyridazine-3,4-dicarboxylic acid diethyl ester (16082-13-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / triethylamine / 1,2-dichloro-ethane / 19 h

2: 100 percent / bromine, acetic acid / 23 h / 23 °C

With bromine; acetic acid; triethylamine; In 1,2-dichloro-ethane;

upstream raw materials:

6-ethoxy-3,4-diethoxycarbonyl-1-methoxycarbonyl-1,4,5,6-tetrahydropyridazine

diethyl 2-(methoxycarbonylhydrazinylidene)butanedioate

diethyl 3-chloro-2-(methoxycarbonylhydrazinylidene)butanedioate

diethyl oxaloacetate

Downstream raw materials:

pyridazine-4-carboxylic acid

pyridazine-3,4-dicarboxylic acid

Refernces

• 1、 Vors, Jean-Pierre. "A Convenient Synthesis of Pyridazine-3,4-dicarboxylic Acid by a Hetero Diels-Alder Reaction". . p. 579 - 582. Retrieved 2007/10/02.