Cyclohexylidenemethyl-benzene

Base Information

• Chemical Name: Cyclohexylidenemethyl-benzene
• CAS No.: 1608-31-7
• Molecular Formula: C13H16
• Molecular Weight: 172.27
• Hs Code.: 2902909090
• Mol file: 1608-31-7.mol

Synonyms:Cyclohexyliden-phenyl-methan;benzylidene-cyclohexane;phenylmethylenecyclohexane;cyclohexylidene-phenyl-methane;benzylidene-6-aminoquinoline;benzylidene-6-quinolylamine;6-Benzylideneaminoquinoline;N-benzylidene-6-aminoquinoline;

Chemical Property of Cyclohexylidenemethyl-benzene

Chemical Property:

• PSA: 0.00000
• LogP: 4.03410

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclohexylidenemethyl-benzene

There total 105 articles about Cyclohexylidenemethyl-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

iodobenzene (591-50-4) + (cyclohexylidenemethyl)tris(trimethylsilyl)silane (718615-43-1) → (cyclohexylidenemethyl)benzene (1608-31-7)

Guidance literature:

With sodium hydroxide; tetrabutyl ammonium fluoride; dihydrogen peroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; water; at 55 ℃; for 10h;

DOI:10.1016/j.tet.2008.03.024

Reference yield: 80.0%

benzyltriphenylphosphonium bromide (1449-46-3) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → (cyclohexylidenemethyl)benzene (1608-31-7)

Guidance literature:

benzyltriphenylphosphonium bromide; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h;

cyclohexanone; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 4h;

DOI:10.1021/jacs.9b13305

Reference yield: 80.0%

1-(Bromo-phenyl-methyl)-cyclohexanecarboxylic acid methyl ester (86951-95-3) → (cyclohexylidenemethyl)benzene (1608-31-7)

Guidance literature:

In N,N,N,N,N,N-hexamethylphosphoric triamide; at 140 - 145 ℃;

DOI:10.1016/S0040-4039(00)81685-8

upstream raw materials:

cyclohexylphenylmethanol

3-phenyl-1-oxaspiro[3.5]nonan-2-one

(E)-2-benzylidenecyclohexanone

1-cyclohexanol

Downstream raw materials:

Cyclohexyliden-benzylbromid

1-benzylcyclohexene

(cyclohexylmethyl)benzene

cyclohexanone

Refernces

• 1、 Alkayal, Anas,Buckley, Benjamin R.,Malkov, Andrei V.,Montanaro, Stephanie,Tabas, Volodymyr,Wright, Iain A.. "Harnessing Applied Potential: Selective β-Hydrocarboxylation of Substituted Olefins". supporting information. . Retrieved 2020/02/13.
• 2、 Zhou, Sen,Yuan, Fangyuan,Guo, Minjie,Wang, Guangwei,Tang, Xiangyang,Zhao, Wentao. "Switchable Synthetic Strategy toward Trisubstituted and Tetrasubstituted Exocyclic Alkenes". supporting information. p. 6710 - 6714. Retrieved 2018/11/21.