(2S)-4-Oxo-1-(9-phenylfluorenyl)-proline Methyl Ester

Base Information

Chemical Name:(2S)-4-Oxo-1-(9-phenylfluorenyl)-proline Methyl Ester
CAS No.:160882-76-8
Molecular Formula:C25H21NO3
Molecular Weight:383.447
Hs Code.:
DSSTox Substance ID:DTXSID20473318
Nikkaji Number:J1.236.627B
Wikidata:Q82302648
Mol file:160882-76-8.mol

Synonyms:160882-76-8;(2S)-4-Oxo-1-(9-phenylfluorenyl)-proline Methyl Ester;Methyl (2S)-4-oxo-1-(9-phenylfluoren-9-yl)pyrrolidine-2-carboxylate;L-Proline, 4-oxo-1-(9-phenyl-9H-fluoren-9-yl)-, methyl ester;SCHEMBL7733449;DTXSID20473318;AKOS030241124;AG-E-10488;methyl (s)-4-oxo-1-(9-phenyl-9h-fluoren-9-yl)prolinate

Suppliers and Price of (2S)-4-Oxo-1-(9-phenylfluorenyl)-proline Methyl Ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(2S)-4-Oxo-1-(9-phenylfluorenyl)-prolineMethylEster
250mg
$ 360.00

American Custom Chemicals Corporation
(2S)-4-OXO-1-(9-PHENYLFLUORENYL)-PROLINE METHYL ESTER 95.00%
1G
$ 1871.10

American Custom Chemicals Corporation
(2S)-4-OXO-1-(9-PHENYLFLUORENYL)-PROLINE METHYL ESTER 95.00%
100MG
$ 739.20

Total 2 raw suppliers

Chemical Property of (2S)-4-Oxo-1-(9-phenylfluorenyl)-proline Methyl Ester

Chemical Property:

Vapor Pressure:9.73E-11mmHg at 25°C
Boiling Point:515.6oC at 760 mmHg
PKA:1.34±0.40(Predicted)
Flash Point:265.6oC
PSA：46.61000
Density:1.284g/cm3
LogP:3.71320
Solubility.:Chloroform, Diethyl Ether
XLogP3:4.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:383.15214353
Heavy Atom Count:29
Complexity:618

Purity/Quality:

97% ^*data from raw suppliers

(2S)-4-Oxo-1-(9-phenylfluorenyl)-prolineMethylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C1CC(=O)CN1C2(C3=CC=CC=C3C4=CC=CC=C42)C5=CC=CC=C5
Isomeric SMILES:COC(=O)[C@@H]1CC(=O)CN1C2(C3=CC=CC=C3C4=CC=CC=C42)C5=CC=CC=C5
Uses (2S)-4-Oxo-1-(9-phenylfluorenyl)-proline Methyl Ester (cas# 160882-76-8) is a compound useful in organic synthesis.

Technology Process of (2S)-4-Oxo-1-(9-phenylfluorenyl)-proline Methyl Ester

There total 11 articles about (2S)-4-Oxo-1-(9-phenylfluorenyl)-proline Methyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 179990-59-1
(2S,4R)-4-hydroxy-N-(9'-phenylfluoren-9'-yl)pyrrolidine-2-carboxylic acid methyl ester

: 160882-76-8
(2S)-4-oxo-N-(9'-phenylfluoren-9'-yl)pyrrolidine-2-carboxylic acid methyl ester

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -60 ℃; for 0.5h;
DOI:10.1021/jo9604245

Reference yield: 90.0%

: 55135-66-5
9-bromo-9-phenyl-9H-fluorene

: methyl (2S,4R)-4-hydroxy-pyrrolidine-2-carboxylate hydrochloride

: 160882-76-8
(2S)-4-oxo-N-(9'-phenylfluoren-9'-yl)pyrrolidine-2-carboxylic acid methyl ester

Guidance literature:: methyl (2S,4R)-4-hydroxy-pyrrolidine-2-carboxylate hydrochloride; With chloro-trimethyl-silane; triethylamine; In methanol; dichloromethane; at 0 - 20 ℃; for 2h;

9-bromo-9-phenyl-9H-fluorene; With lead(II) nitrate; In methanol; dichloromethane; at 20 ℃; for 96h;

Reference yield: 90.0%

: methyl (2S)-4-hydroxy-1-(9-phenyl-9H-fluoren-9-yl)pyrrolidine-2-carboxylate

: 160882-76-8
(2S)-4-oxo-N-(9'-phenylfluoren-9'-yl)pyrrolidine-2-carboxylic acid methyl ester

Guidance literature:: methyl (2S)-4-hydroxy-1-(9-phenyl-9H-fluoren-9-yl)pyrrolidine-2-carboxylate; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 1h; Inert atmosphere;

With triethylamine; at -78 - 20 ℃; Inert atmosphere;
DOI:10.1039/c4ob02002b