Benzoic acid, 3-(2-propynyloxy)-, methyl ester

Base Information

• Chemical Name: Benzoic acid, 3-(2-propynyloxy)-, methyl ester
• CAS No.: 160893-68-5
• Molecular Formula: C11H10O3
• Molecular Weight: 190.199

Synonyms:methyl 3-(prop-2-yn-1-yloxy)benzoate;3-prop-2-ynyloxy-benzoic acid methyl ester;methyl 3-(prop-2-ynyloxy)benzoate;3-(prop-2-ynyloxy) methyl benzoate;

Chemical Property of Benzoic acid, 3-(2-propynyloxy)-, methyl ester

Chemical Property:

• PSA: 35.53000
• LogP: 1.48520

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzoic acid, 3-(2-propynyloxy)-, methyl ester

There total 2 articles about Benzoic acid, 3-(2-propynyloxy)-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl 3-hydroxybenzoate (19438-10-9) + propargyl bromide (106-96-7) → m-methoxycarbonylphenyl propargyl ether (160893-68-5)

Guidance literature:

With potassium carbonate; In acetone; toluene; for 24h; Reflux; Inert atmosphere;

DOI:10.1002/anie.201607338

Reference yield:

3-Carboxyphenol (99-06-9) → m-methoxycarbonylphenyl propargyl ether (160893-68-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 16 h / Heating

2: 95 percent / K₂CO₃ / dimethylformamide; toluene / 16 h / 20 °C

With potassium carbonate; In N,N-dimethyl-formamide; toluene;

DOI:10.1039/b615940k

Reference yield: 99.0%

m-methoxycarbonylphenyl propargyl ether (160893-68-5) → methyl 3-hydroxybenzoate (19438-10-9)

Guidance literature:

With boron tribromide; In dichloromethane; at 20 ℃; for 0.166667h;

DOI:10.1021/ol0489898

upstream raw materials:

methyl 3-hydroxybenzoate

propargyl bromide

3-Carboxyphenol

Downstream raw materials:

methyl 3-hydroxybenzoate

3-(prop-2-yn-1-yloxy)benzoic acid

tert-butyl 2-(3-(prop-2-ynyloxy)benzamido)ethylcarbamate

tert-butyl 2,2',2''-(10-(2-oxo-2-(3-(prop-2-ynyloxy)benzamido)ethylamino)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

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