4-hydroxy-6-methyl-3-phenyl-2H-pyrano[3,2-c]quinoline-2,5(6H)-dione

Base Information

• Chemical Name: 4-hydroxy-6-methyl-3-phenyl-2H-pyrano[3,2-c]quinoline-2,5(6H)-dione
• CAS No.: 161185-37-1
• Molecular Formula: C19H13NO4
• Molecular Weight: 319.31100
• Mol file: 161185-37-1.mol

Synonyms:4-Hydroxy-6-methyl-3-phenyl-6H-pyrano[3,2-c]quinoline-2,5-dione;

Chemical Property of 4-hydroxy-6-methyl-3-phenyl-2H-pyrano[3,2-c]quinoline-2,5(6H)-dione

Chemical Property:

• Melting Point: 222 - 224 °C
• PSA: 72.44000
• LogP: 3.01750

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-hydroxy-6-methyl-3-phenyl-2H-pyrano[3,2-c]quinoline-2,5(6H)-dione

There total 3 articles about 4-hydroxy-6-methyl-3-phenyl-2H-pyrano[3,2-c]quinoline-2,5(6H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4-hydroxy-1-methyl-2(1H)-quinolone (1677-46-9) + diethyl 2-phenylmalonate (83-13-6) → 4-hydroxy-6-methyl-3-phenyl-2H-pyrano[3,2-c]quinoline-2,5(6H)-dione (161185-37-1)

Guidance literature:

In diphenylether; at 220 - 280 ℃;

DOI:10.1002/prac.19943360707

Reference yield: 85.0%

(chlorocarbonyl)phenyl ketene (17118-70-6) + 4-hydroxy-1-methyl-2(1H)-quinolone (1677-46-9) → 4-hydroxy-6-methyl-3-phenyl-2H-pyrano[3,2-c]quinoline-2,5(6H)-dione (161185-37-1)

Guidance literature:

In chloroform; at 25 ℃; for 0.333333h;

DOI:10.1055/s-2006-926295

Reference yield:

N-methylaniline (100-61-8) → 4-hydroxy-6-methyl-3-phenyl-2H-pyrano[3,2-c]quinoline-2,5(6H)-dione (161185-37-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / benzene / Heating

2: 85 percent / CHCl₃ / 0.33 h / 25 °C

In chloroform; benzene;

DOI:10.1055/s-2006-926295

upstream raw materials:

4-hydroxy-1-methyl-2(1H)-quinolone

diethyl 2-phenylmalonate

(chlorocarbonyl)phenyl ketene

N-methylaniline

Downstream raw materials:

4-Hydroxy-1-methyl-3-phenylacetyl-1H-quinolin-2-one