Glycine, N-[(2R)-2-(mercaptomethyl)-1-oxo-3-phenylpropyl]-

Base Information

Chemical Name:Glycine, N-[(2R)-2-(mercaptomethyl)-1-oxo-3-phenylpropyl]-
CAS No.:95908-99-9
Molecular Formula:C12H15 N O3 S
Molecular Weight:253.322
Hs Code.:
UNII:GC7MVJ3HGZ
ChEMBL ID:CHEMBL61512
Nikkaji Number:J245.595A
Pharos Ligand ID:GYA1JGA9AFV7
Mol file:95908-99-9.mol

Synonyms:(R)-THIORPHAN;CHEMBL61512;(-)-Thiorphan;Thiorphan, (R)-;Thiorphan, (-)-;95908-99-9;GC7MVJ3HGZ;Glycine, N-[(2R)-2-(mercaptomethyl)-1-oxo-3-phenylpropyl]-;LY-134464;SCHEMBL7312756;BDBM50024096;LY134464;(2-Mercaptomethyl-3-phenyl-propionylamino)-acetic acid;((R)-2-Mercaptomethyl-3-phenyl-propionylamino)-acetic acid;(R) (2-Mercaptomethyl-3-phenyl-propionylamino)-acetic acid;N-[(2R)-2-(Mercaptomethyl)-1-oxo-3-phenylpropyl]glycine

Suppliers and Price of Glycine, N-[(2R)-2-(mercaptomethyl)-1-oxo-3-phenylpropyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Glycine, N-[(2R)-2-(mercaptomethyl)-1-oxo-3-phenylpropyl]-

Chemical Property:

XLogP3:1.3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:253.07726451
Heavy Atom Count:17
Complexity:265

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)CC(CS)C(=O)NCC(=O)O
Isomeric SMILES:C1=CC=C(C=C1)C[C@@H](CS)C(=O)NCC(=O)O

Technology Process of Glycine, N-[(2R)-2-(mercaptomethyl)-1-oxo-3-phenylpropyl]-

There total 7 articles about Glycine, N-[(2R)-2-(mercaptomethyl)-1-oxo-3-phenylpropyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 100431-48-9
N-<2(R)-<(benzoylthio)methyl>-1-oxo-3-phenylpropyl>glycine benzyl ester

: 95908-99-9
(-)-Thiorphan

Guidance literature:: With sodium hydroxide; In methanol; at 0 - 20 ℃; for 2h;
DOI:10.1021/jm00155a027

Reference yield: 91.0%

: 95841-16-0
N-<(2R)-2-<<(phenylmethyl)thio>methyl>-3-phenylpropanoyl>glycine benzyl ester

: 95908-99-9
(-)-Thiorphan

Guidance literature:: With ammonia; sodium; In tetrahydrofuran; at -33 ℃; for 0.25h;
DOI:10.1021/jo00211a008

Reference yield:

: 81110-58-9
2-[(benzoylthio)methyl]-3-phenylpropanoic acid

: 95908-99-9
(-)-Thiorphan

Guidance literature:: Multi-step reaction with 3 steps

2: 88 percent / Et₃N, 1-hydroxybenzotriazole, N,N'-dicyclohexylcarbodiimide / CHCl₃; tetrahydrofuran / Ambient temperature

3: 98 percent / 1N aq. NaOH / methanol / 2 h / 0 - 20 °C

With sodium hydroxide; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; chloroform;
DOI:10.1021/jm00155a027