methyl 7-methoxy-1-(2-methoxy-2-oxoethyl)-2-methyl-3,4-dihydro-1H-phenanthrene-2-carboxylate

Base Information

Chemical Name:methyl 7-methoxy-1-(2-methoxy-2-oxoethyl)-2-methyl-3,4-dihydro-1H-phenanthrene-2-carboxylate
CAS No.:6636-49-3
Molecular Formula:C₂₁H₂₄O₅
Molecular Weight:356.419
Hs Code.:
NSC Number:51556
DSSTox Substance ID:DTXSID20287553

Synonyms:6636-49-3;NSC51556;methyl 7-methoxy-1-(2-methoxy-2-oxoethyl)-2-methyl-3,4-dihydro-1H-phenanthrene-2-carboxylate;DTXSID20287553;NSC-51556

Suppliers and Price of methyl 7-methoxy-1-(2-methoxy-2-oxoethyl)-2-methyl-3,4-dihydro-1H-phenanthrene-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of methyl 7-methoxy-1-(2-methoxy-2-oxoethyl)-2-methyl-3,4-dihydro-1H-phenanthrene-2-carboxylate

Chemical Property:

Vapor Pressure:3.55E-09mmHg at 25°C
Boiling Point:474.6°C at 760 mmHg
Flash Point:206.5°C
Density:1.157g/cm³
XLogP3:3.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:356.16237386
Heavy Atom Count:26
Complexity:533

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1(CCC2=C(C1CC(=O)OC)C=CC3=C2C=CC(=C3)OC)C(=O)OC

Technology Process of methyl 7-methoxy-1-(2-methoxy-2-oxoethyl)-2-methyl-3,4-dihydro-1H-phenanthrene-2-carboxylate

There total 26 articles about methyl 7-methoxy-1-(2-methoxy-2-oxoethyl)-2-methyl-3,4-dihydro-1H-phenanthrene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6636-49-3,32436-56-9,94131-61-0,94132-09-9
methyl 1,2,3,4-tetrahydro-7-methoxy-1α-methoxycarbonylmethyl-2β-methylphenanthrene-2α-carboxylate

Guidance literature:: With palladium on activated charcoal; at 300 ℃;
DOI:10.1007/BF03251062

Reference yield:

: 4242-13-1
7-methoxy-4-methyl-1,2-dihydronaphthalene

: 6636-49-3,32436-56-9,94131-61-0,94132-09-9
methyl 1,2,3,4-tetrahydro-7-methoxy-1α-methoxycarbonylmethyl-2β-methylphenanthrene-2α-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 57 percent / POCl₃ / CH₂Cl₂ / 8 h / Ambient temperature

2: 78 percent / triethylamine / benzene / 30 h / Heating

3: 78.7 percent / 2,3-dichloro-5,6-dicyanobenzoquinone, acetic acid / benzene / 1.) 1 h, ice-bath, 2.) 3 h, room temperature

4: Zn

5: 1.) trimethylchlorosilane, sodium iodide, 2.) acetic acid, zinc / 1.) acetonitrile, 3 h, 2.) 2 h

With chloro-trimethyl-silane; acetic acid; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; sodium iodide; zinc; trichlorophosphate; In dichloromethane; benzene;

Reference yield:

: 4242-13-1
7-methoxy-4-methyl-1,2-dihydronaphthalene

: 6636-49-3,32436-56-9,94131-61-0,94132-09-9
methyl 1,2,3,4-tetrahydro-7-methoxy-1β-methoxycarbonylmethyl-2β-methylphenanthrene-2α-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: 57 percent / POCl₃ / CH₂Cl₂ / 8 h / Ambient temperature

2: 78 percent / triethylamine / benzene / 30 h / Heating

3: 78.7 percent / 2,3-dichloro-5,6-dicyanobenzoquinone, acetic acid / benzene / 1.) 1 h, ice-bath, 2.) 3 h, room temperature

4: Zn

5: 1.) triethylsilane, trifluoroacetic acid, 2.) sodium hydroxide / 1.) dichloromethane, 15 min, ice-salt bath, 30 min, room temperature, 2.) methanol, overnight

6: 88 mg / ethyl acetate

With triethylsilane; sodium hydroxide; acetic acid; triethylamine; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; zinc; trichlorophosphate; In dichloromethane; ethyl acetate; benzene;