tert-butyl N-(2-hydroxy-3-phenylpropyl)carbamate

Base Information

Chemical Name:tert-butyl N-(2-hydroxy-3-phenylpropyl)carbamate
CAS No.:162541-45-9
Molecular Formula:C14H21NO3
Molecular Weight:251.326
Hs Code.:
DSSTox Substance ID:DTXSID40570252

Synonyms:162541-45-9;tert-butyl N-(2-hydroxy-3-phenylpropyl)carbamate;1,1-dimethylethyl (2-hydroxy-3-phenylpropyl)carbamate;SCHEMBL10188447;DTXSID40570252;XFVAFZNANFHLFG-UHFFFAOYSA-N;AKOS030571768;tert-Butyl (2-hydroxy-3-phenylpropyl)carbamate;EN300-4350289;Z1496966914;Carbamic acid, N-(2-hydroxy-3-phenylpropyl)-, 1,1-dimethylethyl ester

Suppliers and Price of tert-butyl N-(2-hydroxy-3-phenylpropyl)carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl N-(2-hydroxy-3-phenylpropyl)carbamate

Chemical Property:

XLogP3:2.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:251.15214353
Heavy Atom Count:18
Complexity:254

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NCC(CC1=CC=CC=C1)O

Technology Process of tert-butyl N-(2-hydroxy-3-phenylpropyl)carbamate

There total 7 articles about tert-butyl N-(2-hydroxy-3-phenylpropyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 50411-26-2
3-phenyl-2-hydroxypropylamine

: 162541-45-9
(RS)-2-<(tert-Butoxycarbonyl)amino>-1-benzylethanol

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield: 60.0%

: 108-86-1,52753-63-6
bromobenzene

: 148982-76-7,149057-20-5,115198-80-6
tert-butyl N-(2-oxiranylmethyl)carbamate

: 162541-45-9
(RS)-2-<(tert-Butoxycarbonyl)amino>-1-benzylethanol

Guidance literature:: With pyridine; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; 4,4'-bipyridine; NiI₂*3.9H₂O; triethylamine hydrochloride; sodium iodide; zinc; at 20 ℃; for 12h;
DOI:10.1021/ja410704d

Reference yield:

: 50353-47-4
phenyl acetaldehyde cyanohydrin

: 162541-45-9
(RS)-2-<(tert-Butoxycarbonyl)amino>-1-benzylethanol

Guidance literature:: Multi-step reaction with 2 steps

1: LiAlH₄ / diethyl ether

2: 89 percent / N-methylmorpholine / CH₂Cl₂ / 0.5 h / Ambient temperature

With 4-methyl-morpholine; lithium aluminium tetrahydride; In diethyl ether; dichloromethane;
DOI:10.1021/jo00121a038