Tropine phenylglycinate dihydrochloride hydrate

Base Information

Chemical Name:Tropine phenylglycinate dihydrochloride hydrate
CAS No.:64790-49-4
Molecular Formula:C₁₆H₂₂N₂O₂*ClH
Molecular Weight:310.824
Hs Code.:
DSSTox Substance ID:DTXSID50983399

Synonyms:Tropine phenylglycinate dihydrochloride hydrate;Tropine phenylglycinate HCl;Tropine phenylglycinate dihydrochloride;Glycine, 2-phenyl-, 1-alpha-H,5-alpha-H-tropan-3-alpha-yl ester, dihydrochloride, hydrate;64790-49-4;DTXSID50983399;C16H22N2O2.2ClH.H2O;LS-72860;C16-H22-N2-O2.2Cl-H.H2-O;8-Methyl-8-azabicyclo[3.2.1]octan-3-yl amino(phenyl)acetate--hydrogen chloride (1/2)

Suppliers and Price of Tropine phenylglycinate dihydrochloride hydrate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Tropine phenylglycinate dihydrochloride hydrate

Chemical Property:

Vapor Pressure:4.8E-06mmHg at 25°C
Boiling Point:382.2°C at 760 mmHg
Flash Point:184.9°C
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:346.1214834
Heavy Atom Count:22
Complexity:340

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C2CCC1CC(C2)OC(=O)C(C3=CC=CC=C3)N.Cl.Cl

Technology Process of Tropine phenylglycinate dihydrochloride hydrate

There total 3 articles about Tropine phenylglycinate dihydrochloride hydrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2900-27-8,3601-66-9,14675-97-9,33125-05-2
2-(tert-butoxycarbonylamino)-2-phenylacetic acid

: 64790-49-4
(1R,3r,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 2-amino-2-phenylacetate hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / 18 h / 20 °C

2: hydrogenchloride / 1,4-dioxane / 20 h / 20 °C

With hydrogenchloride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1021/acs.jmedchem.1c00204

Reference yield:

: C₂₁H₃₀N₂O₄

: 64790-49-4
(1R,3r,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 2-amino-2-phenylacetate hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 20h;
DOI:10.1021/acs.jmedchem.1c00204

Reference yield:

: 2835-06-5
phenylglycin

: 64790-49-4
(1R,3r,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 2-amino-2-phenylacetate hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide; sodium hydrogencarbonate / water; 1,4-dioxane / 24 h / 0 - 20 °C

2: dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / 18 h / 20 °C

3: hydrogenchloride / 1,4-dioxane / 20 h / 20 °C

With hydrogenchloride; sodium hydrogencarbonate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; water;
DOI:10.1021/acs.jmedchem.1c00204