methyl (E)-3-(3-aminophenyl)acrylate

Base Information

• Chemical Name: methyl (E)-3-(3-aminophenyl)acrylate
• CAS No.: 163487-10-3
• Molecular Formula: C10H11NO2
• Molecular Weight: 0.00000
• Mol file: 163487-10-3.mol

Synonyms:

Chemical Property of methyl (E)-3-(3-aminophenyl)acrylate

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99% ^*data from raw suppliers

Methyl(E)-3-(3-aminophenyl)acrylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (E)-3-(3-aminophenyl)acrylate

There total 12 articles about methyl (E)-3-(3-aminophenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl 3-nitrocinnamate (659-04-1) → 3-(3-amino-phenyl)-acrylic acid methyl ester (58186-45-1,163487-10-3)

Guidance literature:

With tin(ll) chloride; In methanol; at 65 ℃; for 2h;

Reference yield: 92.0%

acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) + 3-Iodoaniline (626-01-7) → 3-(3-amino-phenyl)-acrylic acid methyl ester (58186-45-1,163487-10-3)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 130 ℃; for 4h; Catalytic behavior;

DOI:10.1016/j.mcat.2017.09.022

Reference yield: 86.0%

3-(3-nitrophenyl)acrylic acid methyl ester (1664-59-1) → methyl 3-aminocinnamate (58186-45-1,163487-10-3)

Guidance literature:

With hydrogenchloride; iron; In methanol; water; for 15h; Reflux;

upstream raw materials:

methyl 3-nitrocinnamate

(E)-3-Nitrocinnamic acid

3-nitro-benzaldehyde

m-iodonitrobenzene

Downstream raw materials:

7-(3-amino-phenyl)-[1,4]thiazepan-5-one

Refernces

• 1、 Yang, Lei,Xue, Xiaowen,Zhang, Yihua. "Simple and efficient synthesis of belinostat". . p. 2520 - 2524. Retrieved 2010.
• 2、 Bokosi, Fostino R. B.,Beteck, Richard M.,Laming, Dustin,Hoppe, Heinrich C.,Tshiwawa, Tendamudzimu,Khanye, Setshaba D.. "Synthesis of 2-(N-cyclicamino)quinoline combined with methyl (E)-3-(2/3/4-aminophenyl)acrylates as potential antiparasitic agents". . . Retrieved 2021/03/16.
• 3、 -. "SUBSTITUTED AMIDE COMPOUNDS USEFUL AS FARNESOID X RECEPTOR MODULATORS". Page/Page column 83. . Retrieved 2020/08/28.