(+)-N--L-prolyl>-L-phenylalanine methyl ester

Base Information

• Chemical Name: (+)-N--L-prolyl>-L-phenylalanine methyl ester
• CAS No.: 124731-70-0
• Molecular Formula: C₃₂H₄₀N₄O₇
• Molecular Weight: 592.692
• Mol file: 124731-70-0.mol

Synonyms:

Chemical Property of (+)-N--L-prolyl>-L-phenylalanine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+)-N--L-prolyl>-L-phenylalanine methyl ester

There total 5 articles about (+)-N--L-prolyl>-L-phenylalanine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

t-Boc-L-valine (13734-41-3) + methyl 2-isocyano-3-phenylpropanoate (63526-79-4) + 4-(4,5-Dihydro-3H-pyrrol-3-yloxy)-benzonitrile (124817-90-9) → (R)-2-{[(2S,3S)-1-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyryl)-3-(4-cyano-phenoxy)-pyrrolidine-2-carbonyl]-amino}-3-phenyl-propionic acid methyl ester (124731-78-8) + (R)-2-{[(2S,3R)-1-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyryl)-3-(4-cyano-phenoxy)-pyrrolidine-2-carbonyl]-amino}-3-phenyl-propionic acid methyl ester (124731-79-9) + (R)-2-{[(2R,3S)-1-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyryl)-3-(4-cyano-phenoxy)-pyrrolidine-2-carbonyl]-amino}-3-phenyl-propionic acid methyl ester (124731-82-4) + (+)-N--L-prolyl>-L-phenylalanine methyl ester (124731-70-0)

Guidance literature:

Further byproducts given; 1) reflux, 3.5 h, 2) room temperature, 12 h;

Reference yield:

t-Boc-L-valine (13734-41-3) + methyl 2-isocyano-3-phenylpropanoate (63526-79-4) + 4-(4,5-Dihydro-3H-pyrrol-3-yloxy)-benzonitrile (124817-90-9) → (R)-2-{[(2S,3S)-1-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyryl)-3-(4-cyano-phenoxy)-pyrrolidine-2-carbonyl]-amino}-3-phenyl-propionic acid methyl ester (124731-78-8) + (R)-2-{[(2S,3R)-1-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyryl)-3-(4-cyano-phenoxy)-pyrrolidine-2-carbonyl]-amino}-3-phenyl-propionic acid methyl ester (124731-79-9) + (S)-2-{[(2S,3R)-1-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyryl)-3-(4-cyano-phenoxy)-pyrrolidine-2-carbonyl]-amino}-3-phenyl-propionic acid methyl ester (124731-80-2) + (+)-N--L-prolyl>-L-phenylalanine methyl ester (124731-70-0)

Guidance literature:

Further byproducts given; 1) reflux, 3.5 h, 2) room temperature, 12 h;

Reference yield:

t-Boc-L-valine (13734-41-3) + methyl 2-isocyano-3-phenylpropanoate (63526-79-4) + 4-(4,5-Dihydro-3H-pyrrol-3-yloxy)-benzonitrile (124817-90-9) → (R)-2-{[(2S,3S)-1-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyryl)-3-(4-cyano-phenoxy)-pyrrolidine-2-carbonyl]-amino}-3-phenyl-propionic acid methyl ester (124731-78-8) + (R)-2-{[(2S,3R)-1-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyryl)-3-(4-cyano-phenoxy)-pyrrolidine-2-carbonyl]-amino}-3-phenyl-propionic acid methyl ester (124731-79-9) + (S)-2-{[(2R,3S)-1-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyryl)-3-(4-cyano-phenoxy)-pyrrolidine-2-carbonyl]-amino}-3-phenyl-propionic acid methyl ester (124731-81-3) + (+)-N--L-prolyl>-L-phenylalanine methyl ester (124731-70-0)

Guidance literature:

Further byproducts given; 1) reflux, 3.5 h, 2) room temperature, 12 h;

upstream raw materials:

t-Boc-L-valine

methyl 2-isocyano-3-phenylpropanoate

4-(4,5-Dihydro-3H-pyrrol-3-yloxy)-benzonitrile

Downstream raw materials:

(+)-N--L-prolyl>-L-phenylalanine methyl ester