Technology Process of Pyrrolo[3,2-c]azepin-4(1H)-one,
5,6,7,8-tetrahydro-1-(4-methoxyphenyl)-2,7,7-trimethyl-
There total 4 articles about Pyrrolo[3,2-c]azepin-4(1H)-one,
5,6,7,8-tetrahydro-1-(4-methoxyphenyl)-2,7,7-trimethyl- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 81 percent / acetic acid / 12 h / Heating
2: 97 percent / hydroxylamine hydrochloride; sodium hydroxide / ethanol; H2O / 2 h / Heating
3: 95 percent / phosphorus pentoxide; phosphoric acid / 2 h / 80 - 90 °C
With
phosphorus pentaoxide; sodium hydroxide; phosphoric acid; hydroxylamine hydrochloride; acetic acid;
In
ethanol; water;
1: Paal-Knorr reaction / 3: Beckmann rearrangement;
DOI:10.1016/j.bmc.2006.02.012
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 70 percent / potassium carbonate / CHCl3 / 48 h / 20 °C
2: 81 percent / acetic acid / 12 h / Heating
3: 97 percent / hydroxylamine hydrochloride; sodium hydroxide / ethanol; H2O / 2 h / Heating
4: 95 percent / phosphorus pentoxide; phosphoric acid / 2 h / 80 - 90 °C
With
phosphorus pentaoxide; sodium hydroxide; phosphoric acid; hydroxylamine hydrochloride; potassium carbonate; acetic acid;
In
ethanol; chloroform; water;
2: Paal-Knorr reaction / 4: Beckmann rearrangement;
DOI:10.1016/j.bmc.2006.02.012
