(1,3-diphenyl-1H-pyrazol-5-yl)methanol

Base Information

Chemical Name:(1,3-diphenyl-1H-pyrazol-5-yl)methanol
CAS No.:16492-63-0
Molecular Formula:C16H14N2O
Molecular Weight:250.29500
Hs Code.:2933199090
DSSTox Substance ID:DTXSID90575075
Nikkaji Number:J3.360.749K
Wikidata:Q82464312
Mol file:16492-63-0.mol

Synonyms:16492-63-0;(1,3-diphenyl-1H-pyrazol-5-yl)methanol;1H-Pyrazole-5-methanol, 1,3-diphenyl-;(2,5-DIPHENYLPYRAZOL-3-YL)METHANOL;5-HYDROXYMETHYL-N,3-DIPHENYL-PYRAZOLE;DTXSID90575075;XOUHWULVDNZGAI-UHFFFAOYSA-N

Suppliers and Price of (1,3-diphenyl-1H-pyrazol-5-yl)methanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
5-HYDROXYMETHYL-N-3-DIPHENYL-PYRAZOLE 95.00%
5MG
$ 495.44

Total 1 raw suppliers

Chemical Property of (1,3-diphenyl-1H-pyrazol-5-yl)methanol

Chemical Property:

Boiling Point:443.6±30.0 °C(Predicted)
PSA：38.05000
Density:1.15±0.1 g/cm3(Predicted)
LogP:3.03160
XLogP3:2.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:250.110613074
Heavy Atom Count:19
Complexity:272

Purity/Quality:

99% ^*data from raw suppliers

5-HYDROXYMETHYL-N-3-DIPHENYL-PYRAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)C2=NN(C(=C2)CO)C3=CC=CC=C3

Technology Process of (1,3-diphenyl-1H-pyrazol-5-yl)methanol

There total 11 articles about (1,3-diphenyl-1H-pyrazol-5-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 536-74-3
phenylacetylene

: 4-(hydroxymethyl)-3-phenyl-1,2,3-oxadiazol-3-ium-5-olate

: 16492-63-0
(1,3-diphenyl-1H-pyrazol-5-yl)methanol

Guidance literature:: In 1,2-dichloro-benzene; at 180 ℃; for 24h; regioselective reaction; Sealed tube;
DOI:10.1021/jo400381a

Reference yield: 33.0%

: 5-(bromomethyl)-1,3-diphenyl-1H-pyrazole

: 16492-63-0
(1,3-diphenyl-1H-pyrazol-5-yl)methanol

Guidance literature:: With silver hexafluoroantimonate; In acetonitrile; at 20 ℃; for 12h;
DOI:10.1039/d1cc02735b

Reference yield:

: 588-64-7
benzaldehyde phenylhydrazone

: 16492-63-0
(1,3-diphenyl-1H-pyrazol-5-yl)methanol

Guidance literature:: Multi-step reaction with 3 steps

1: dimethylsulfide; N-chloro-succinimide / dichloromethane / 1 h / -40 - 0 °C

2: potassium carbonate / chloroform / 24 h / 0 °C / Inert atmosphere

3: silver hexafluoroantimonate / acetonitrile / 12 h / 20 °C

With N-chloro-succinimide; silver hexafluoroantimonate; dimethylsulfide; potassium carbonate; In dichloromethane; chloroform; acetonitrile;
DOI:10.1039/d1cc02735b