2-Acetyl-1-methyl-1H-indole

Base Information

• Chemical Name: 2-Acetyl-1-methyl-1H-indole
• CAS No.: 16498-68-3
• Molecular Formula: C11H11NO
• Molecular Weight: 173.214
• Hs Code.: 2933990090
• Mol file: 16498-68-3.mol

Synonyms:N-methyl-2-acetylindole;2-Acetyl-1-methyl-1H-indole;1-methyl-2-acetyl indole;2-Acetyl-1-methylindole;

Chemical Property of 2-Acetyl-1-methyl-1H-indole

Chemical Property:

• PSA: 22.00000
• LogP: 2.38090

Purity/Quality:

97% ^*data from raw suppliers

1-(1-Methyl-1H-indol-2-yl)ethanone 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Acetyl-1-methyl-1H-indole

There total 25 articles about 2-Acetyl-1-methyl-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.5%

N-methoxy-N-methyl-1-methylindole-2-carboxamide (548489-89-0) → 1-(1-methyl-1H-indol-2-yl)ethanone (16498-68-3)

Guidance literature:

With methyllithium; In tetrahydrofuran; hexane; water; at -78 - 20 ℃; for 1h; Inert atmosphere;

Reference yield: 79.0%

methyllithium (917-54-4) + N-methoxyurea-N,N',N'-trimethylurea (123707-27-7) + 2-lithio-1-methylindole (54852-26-5) → 1-(1-methyl-1H-indol-2-yl)ethanone (16498-68-3)

Guidance literature:

In tetrahydrofuran; 1) from -78 deg C to -20 deg C, 1 h; 2) from -78 deg C to room temperature, 1.5 h;

DOI:10.1016/S0040-4039(00)99576-5

Reference yield: 75.0%

1-methyl-1H-indole-2-carboxaldehyde (27421-51-8) + dimethyl 1-(1-diazo-2-oxopropyl)phosphonate (90965-06-3) → 1-(1-methyl-1H-indol-2-yl)ethanone (16498-68-3)

Guidance literature:

1-methyl-1H-indole-2-carboxaldehyde; dimethyl 1-(1-diazo-2-oxopropyl)phosphonate; With potassium tert-butylate; In methanol; at 100 ℃; for 0.5h;

With water; In methanol;

upstream raw materials:

butane-2,3-dione-mono-(methyl-phenyl-hydrazone)

methyllithium

N-methoxyurea-N,N',N'-trimethylurea

2-lithio-1-methylindole

Downstream raw materials:

2-Cyano-1-methyl-3-<2-<(1-methyl-2-indolyl)carbonyl>ethyl>-4-(phenylsulfonyl)piperidine

2-Cyano-1-methyl-3-<2-<(1-methyl-2-indolyl)carbonyl>ethyl>-4-(phenylsulfonyl)piperidine