4-acetyl-1H-quinolin-2-one

Base Information

Chemical Name:4-acetyl-1H-quinolin-2-one
CAS No.:16511-39-0
Molecular Formula:C11H9NO2
Molecular Weight:187.19500
Hs Code.:2933790090
DSSTox Substance ID:DTXSID70345435
Nikkaji Number:J103.758G
Wikidata:Q82117936
Mol file:16511-39-0.mol

Synonyms:4-acetyl-1H-quinolin-2-one;4-Acetyl-2(1H)-quinolinone;Carbostyril, 4-acetyl-;2(1H)-Quinolinone, 4-acetyl-;16511-39-0;4-Acetyl-2-quinolinone;4-acetylquinolin-2(1h)-one;SCHEMBL10202038;4-Acetyl-2(1H)-quinolinone #;DTXSID70345435

Suppliers and Price of 4-acetyl-1H-quinolin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 4-acetyl-1H-quinolin-2-one

Chemical Property:

Melting Point:194-195 °C
Boiling Point:436.6±45.0 °C(Predicted)
PKA:10.86±0.70(Predicted)
PSA：50.19000
Density:1.236±0.06 g/cm3(Predicted)
LogP:2.14300
XLogP3:0.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:187.063328530
Heavy Atom Count:14
Complexity:306

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)C1=CC(=O)NC2=CC=CC=C21

Technology Process of 4-acetyl-1H-quinolin-2-one

There total 5 articles about 4-acetyl-1H-quinolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 16511-39-0
C₁₁H₉NO₂

Guidance literature:

Reference yield:

: C₁₅H₁₇NO₂

: 16511-39-0
4-Acetyl-carbostyril

Guidance literature:: With hydrogenchloride; water; In 1,4-dioxane; at 0 ℃; for 2h;
DOI:10.1016/j.tetlet.2011.04.033

Reference yield:

: 685890-47-5
2-oxo-1,2-dihydroquinolin-4-yl 4-methylbenzenesulfonate

: 16511-39-0
4-Acetyl-carbostyril

Guidance literature:: Multi-step reaction with 2 steps

1: 1,3-bis-(diphenylphosphino)propane; palladium diacetate; N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 5 h / 80 °C / Inert atmosphere

2: hydrogenchloride; water / 1,4-dioxane / 2 h / 0 °C

With hydrogenchloride; 1,3-bis-(diphenylphosphino)propane; water; palladium diacetate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; 1: Heck reaction;
DOI:10.1016/j.tetlet.2011.04.033