8-BROMO-6-CHLOROQUINOLINE

Base Information

• Chemical Name: 8-BROMO-6-CHLOROQUINOLINE
• CAS No.: 16567-11-6
• Molecular Formula: C9H5BrClN
• Molecular Weight: 242.4997
• Hs Code.: 2933499090
• Mol file: 16567-11-6.mol

Synonyms:8-BROMO-6-CHLOROQUINOLINE;8-BroMo-6-chloroquinolilne

Chemical Property of 8-BROMO-6-CHLOROQUINOLINE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 93.5-94.0 °C
• Refractive Index: 1.68
• Boiling Point: 327.771 °C at 760 mmHg
• PKA: 1.53±0.20(Predicted)
• Flash Point: 152.031 °C
• PSA: 12.89000
• Density: 1.673g/cm³
• LogP: 3.65070
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

8-Bromo-6-chloroquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-BROMO-6-CHLOROQUINOLINE

There total 5 articles about 8-BROMO-6-CHLOROQUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

8--bromo--6--methoxyquinoline (50488-36-3) → 8-Bromo-6-chloroquinoline (16567-11-6)

Guidance literature:

Reference yield:

8-bromoquinolin-6-amine (858420-01-6) → 8-Bromo-6-chloroquinoline (16567-11-6)

Guidance literature:

With hydrogenchloride; copper(l) chloride; sodium nitrite; In water; at 0 ℃; for 0.85h;

Reference yield:

6-nitroquinoline (613-50-3) → 8-Bromo-6-chloroquinoline (16567-11-6)

Guidance literature:

Multi-step reaction with 3 steps

1: N-Bromosuccinimide; sulfuric acid / ethyl acetate / 60 °C / Cooling with ice

2: iron; ammonium chloride / water; ethanol / 3 h / Reflux

3: hydrogenchloride; sodium nitrite; copper(l) chloride / water / 0.85 h / 0 °C

With hydrogenchloride; N-Bromosuccinimide; sulfuric acid; iron; ammonium chloride; copper(l) chloride; sodium nitrite; In ethanol; water; ethyl acetate;

upstream raw materials:

8--bromo--6--methoxyquinoline

6-nitroquinoline

6-nitro-8-bromoquinoline

8-bromoquinolin-6-amine

Downstream raw materials:

6,8-diphenylquinoline

Refernces

• 1、 -. "Aryl-8-azabicyclo [3.2.1] octanes for the treatment of depression". . . Retrieved 2008/06/13.