S-DIDEMETHYL CITALOPRAM

Base Information

• Chemical Name: S-DIDEMETHYL CITALOPRAM
• CAS No.: 166037-78-1
• Molecular Formula: C18H17FN2O
• Molecular Weight: 296.344
• Mol file: 166037-78-1.mol

Synonyms:(+)-Didemethylcitalopram;(+)-1-(3-aminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile;S-(+)-didesmethyl citalopram;(S)-N-didemethyl-citalopram;

Chemical Property of S-DIDEMETHYL CITALOPRAM

Chemical Property:

• PSA: 59.04000
• LogP: 3.91038

Purity/Quality:

99% ^*data from raw suppliers

S-DidemethylCitalopram ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: S-DIDEMETHYL CITALOPRAM is a metabolite of Citalopram, an inhibitor of serotonin (5-HT) uptake. Used as an antidepressant. [a]=+14.1

Technology Process of S-DIDEMETHYL CITALOPRAM

There total 3 articles about S-DIDEMETHYL CITALOPRAM which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

didesmethylcitalopram (62498-69-5) → (+)-Didemethylcitalopram (166037-78-1)

Guidance literature:

With Di-p-toluoyl-L-tartaric acid; In acetonitrile; at 20 - 65 ℃; for 0.75 - 1h;

Reference yield:

C23H25FN2O3 → (+)-Didemethylcitalopram (166037-78-1)

Guidance literature:

C₂₃H₂₅FN₂O₃; With trifluoroacetic acid; at 20 ℃; for 1h;

With potassium carbonate; In water; ethyl acetate;

Reference yield:

(+)-Desmethylcitalopram (144025-14-9,144010-85-5) → (+)-Didemethylcitalopram (166037-78-1)

Guidance literature:

With cDNA-expressed human CYP₂D₆ enzyme; In phosphate buffer; at 37 ℃; for 1h; pH=7.4; Further Variations:; substrate concentration; Enzyme kinetics;

DOI:10.1159/000028333

upstream raw materials:

(+)-Desmethylcitalopram

didesmethylcitalopram

Downstream raw materials:

escitalopram

(S)-N-{3-[5-cyano-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-1-yl]propyl}formamide

Refernces

• 1、 -. "Treatment or prophylaxis of migraine or headache disorders using citalopram, escitalopram or citalopram metabolites". Page/Page column 11. . Retrieved 2010/02/13.