Carbamic acid, [3-[cyclopropyl(5,6,7,8,9,10-hexahydro-4-hydroxy-2-oxo-2H-cycloocta[b ]pyran-3-yl)methyl]phenyl]-, phenylmethyl ester

Base Information

• Chemical Name: Carbamic acid, [3-[cyclopropyl(5,6,7,8,9,10-hexahydro-4-hydroxy-2-oxo-2H-cycloocta[b ]pyran-3-yl)methyl]phenyl]-, phenylmethyl ester
• CAS No.: 166282-28-6
• Molecular Formula: C₂₉H₃₁NO₅
• Molecular Weight: 473.569
• Mol file: 166282-28-6.mol

Synonyms:

Chemical Property of Carbamic acid, [3-[cyclopropyl(5,6,7,8,9,10-hexahydro-4-hydroxy-2-oxo-2H-cycloocta[b ]pyran-3-yl)methyl]phenyl]-, phenylmethyl ester

Chemical Property:

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Technology Process of Carbamic acid, [3-[cyclopropyl(5,6,7,8,9,10-hexahydro-4-hydroxy-2-oxo-2H-cycloocta[b ]pyran-3-yl)methyl]phenyl]-, phenylmethyl ester

There total 1 articles about Carbamic acid, [3-[cyclopropyl(5,6,7,8,9,10-hexahydro-4-hydroxy-2-oxo-2H-cycloocta[b ]pyran-3-yl)methyl]phenyl]-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

5,6,7,8,9,10-Hexahydro-4-hydroxy-2H-cyclooctapyran-2-on (100058-82-0) + m-<(benzyloxycarbonyl)amino>phenyl cyclopropyl carbinol (162174-77-8) → <3-pyran-3-yl)methyl>phenyl>carbamic acid, phenylmethyl ester (166282-28-6,166335-05-3)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; for 16h; Ambient temperature;

DOI:10.1021/jm00022a011

Reference yield: 100.0%

<3-pyran-3-yl)methyl>phenyl>carbamic acid, phenylmethyl ester (166282-28-6,166335-05-3) → 3-<(3-aminophenyl)cyclopropylmethyl>-5,6,7,8,9,10-hexahydro-4-hydroxy-2H-cyclooctapyran-2-one (166282-70-8,166335-06-4,166335-07-5)

Guidance literature:

With cyclohexene; palladium on activated charcoal;

Reference yield:

<3-pyran-3-yl)methyl>phenyl>carbamic acid, phenylmethyl ester (166282-28-6,166335-05-3) → N-[3-[Cyclopropyl(5,6,7,8,9,10-hexahydro-4-hydroxy-2-oxo-2H-cycloocta[b]pyran-3-yl)methyl]phenyl]-methanesulfonamide

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / 10percent Pd/C / methanol / 18 h / 2482.3 Torr

2: 59 percent / pyridine / CH₂Cl₂ / 18 h / Ambient temperature

With pyridine; hydrogen; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1021/jm960441m

upstream raw materials:

5,6,7,8,9,10-Hexahydro-4-hydroxy-2H-cyclooctapyran-2-on

m-<(benzyloxycarbonyl)amino>phenyl cyclopropyl carbinol

Downstream raw materials:

3-<(3-aminophenyl)cyclopropylmethyl>-5,6,7,8,9,10-hexahydro-4-hydroxy-2H-cyclooctapyran-2-one

{3-[(R)-Cyclopropyl-(4-hydroxy-2-oxo-5,6,7,8,9,10-hexahydro-2H-cycloocta[b]pyran-3-yl)-methyl]-phenyl}-carbamic acid benzyl ester

U 103017

N-methyl-3[(3-aminophenyl)cyclopropylmethyl]-5,6,7,8,9,10-hexahydro-4-hydroxy-2H-cycloocta[b]pyran-2-one

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