Carbamic acid, [3-[1-(5,6,7,8,9,10-hexahydro-4-hydroxy-2-oxo-2H-cycloocta[b]pyran-3- yl)butyl]phenyl]-, phenylmethyl ester

Base Information

• Chemical Name: Carbamic acid, [3-[1-(5,6,7,8,9,10-hexahydro-4-hydroxy-2-oxo-2H-cycloocta[b]pyran-3- yl)butyl]phenyl]-, phenylmethyl ester
• CAS No.: 166336-29-4
• Molecular Formula: C29H33NO5
• Molecular Weight: 475.585
• Mol file: 166336-29-4.mol

Synonyms:

Chemical Property of Carbamic acid, [3-[1-(5,6,7,8,9,10-hexahydro-4-hydroxy-2-oxo-2H-cycloocta[b]pyran-3- yl)butyl]phenyl]-, phenylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Useful:

Technology Process of Carbamic acid, [3-[1-(5,6,7,8,9,10-hexahydro-4-hydroxy-2-oxo-2H-cycloocta[b]pyran-3- yl)butyl]phenyl]-, phenylmethyl ester

There total 6 articles about Carbamic acid, [3-[1-(5,6,7,8,9,10-hexahydro-4-hydroxy-2-oxo-2H-cycloocta[b]pyran-3- yl)butyl]phenyl]-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

5,6,7,8,9,10-Hexahydro-4-hydroxy-2H-cyclooctapyran-2-on (100058-82-0) + [3-(1-Hydroxybutyl)phenyl]-carbamic acid, phenylmethyl ester (166337-68-4) → [3-[1-(5,6,7,8,9,10-Hexahydro-4-hydroxy-2-oxo-2H-cycloocta[b]pyran-3-yl)butyl]phenyl]-carbamic acid, phenylmethyl ester (166336-29-4)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; at 20 ℃; for 72h;

DOI:10.1021/jm960441m

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → [3-[1-(5,6,7,8,9,10-Hexahydro-4-hydroxy-2-oxo-2H-cycloocta[b]pyran-3-yl)butyl]phenyl]-carbamic acid, phenylmethyl ester (166336-29-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 77 percent / NaHCO₃ / tetrahydrofuran; H₂O / 0.67 h / Ambient temperature

2: 79 percent / tetrahydrofuran / 18 h / Ambient temperature

3: 18 percent / p-toluenesulfonic acid / toluene / 72 h / 20 °C

With sodium hydrogencarbonate; toluene-4-sulfonic acid; In tetrahydrofuran; water; toluene;

DOI:10.1021/jm960441m

Reference yield:

3-((benzyloxycarbonyl)amino)benzaldehyde (166337-67-3) → [3-[1-(5,6,7,8,9,10-Hexahydro-4-hydroxy-2-oxo-2H-cycloocta[b]pyran-3-yl)butyl]phenyl]-carbamic acid, phenylmethyl ester (166336-29-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / tetrahydrofuran / 18 h / Ambient temperature

2: 18 percent / p-toluenesulfonic acid / toluene / 72 h / 20 °C

With toluene-4-sulfonic acid; In tetrahydrofuran; toluene;

DOI:10.1021/jm960441m

upstream raw materials:

5,6,7,8,9,10-Hexahydro-4-hydroxy-2H-cyclooctapyran-2-on

[3-(1-Hydroxybutyl)phenyl]-carbamic acid, phenylmethyl ester

benzyl chloroformate

3-((benzyloxycarbonyl)amino)benzaldehyde

Downstream raw materials:

3-[1-(3-Aminophenyl)butyl]-5,6,7,8,9,10-hexahydro4-hydroxy-2H-cycloocta[b]pyran-2-one

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