Glycine, N-[N-[(phenylmethoxy)carbonyl]-L-threonyl]-, methyl ester

Base Information

• Chemical Name: Glycine, N-[N-[(phenylmethoxy)carbonyl]-L-threonyl]-, methyl ester
• CAS No.: 1677-00-5
• Molecular Formula: C15H20N2O6
• Molecular Weight: 324.334
• Mol file: 1677-00-5.mol

Synonyms:

Chemical Property of Glycine, N-[N-[(phenylmethoxy)carbonyl]-L-threonyl]-, methyl ester

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Glycine, N-[N-[(phenylmethoxy)carbonyl]-L-threonyl]-, methyl ester

There total 2 articles about Glycine, N-[N-[(phenylmethoxy)carbonyl]-L-threonyl]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N-benzyloxycarbonyl-L-treonine (19728-63-3) + glycine ethyl ester hydrochloride (5680-79-5,883886-67-7) → methyl ((benzyloxy)carbonyl)-L-threonylglycinate (1677-00-5)

Guidance literature:

With sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 - 20 ℃; for 48h; Inert atmosphere;

DOI:10.1016/j.tetlet.2021.153175

Reference yield: 78.0%

N-benzyloxycarbonyl-L-treonine (19728-63-3) + methoxycarbonylmethylamine (616-34-2) → methyl ((benzyloxy)carbonyl)-L-threonylglycinate (1677-00-5)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide;

DOI:10.1021/ja00094a008

Reference yield: 83.0%

methyl ((benzyloxy)carbonyl)-L-threonylglycinate (1677-00-5) → N-benzyloxycarbonyl-N'-methoxycarbonylmethyloxamide (95930-68-0)

Guidance literature:

With ruthenium trichloride; sodium periodate; In tetrachloromethane; water; acetonitrile; for 1.5h; Ambient temperature; pH 3 phosphate buffer;

DOI:10.1021/ja00003a048

upstream raw materials:

N-benzyloxycarbonyl-L-treonine

glycine ethyl ester hydrochloride

methoxycarbonylmethylamine

Downstream raw materials:

N-benzyloxycarbonyl-N'-methoxycarbonylmethyloxamide

Refernces

• 1、 Ferreira, Paula M.T.,Maia, Hernani L.S.,Monteiro, Luis S.,Sacramento, Joana. "High yielding synthesis of dehydroamino acid and dehydropeptide derivatives". . p. 3697 - 3703. Retrieved 2007/10/03.
• 2、 Schaich,Schneider. "Synthesis of a fragment of the active center sequence of the streptococcal proteinase, III". . p. 952 - 957. Retrieved 2007/10/07.