3-METHYL-1,2,3-TRIAZOLO(1,5-A)PYRIDINE

Base Information

• Chemical Name: 3-METHYL-1,2,3-TRIAZOLO(1,5-A)PYRIDINE
• CAS No.: 54856-82-5
• Molecular Formula: C7H7N3
• Molecular Weight: 133.153
• Hs Code.: 2933990090
• Mol file: 54856-82-5.mol

Synonyms:v-Triazolo[1,5-a]pyridine,3-methyl- (6CI);3-Methyl-1,2,3-triazolo[1,5-a]pyridine;NSC 259157;3-Methyl[1,2,3]triazolo[1,5-a]pyridine;3-Methyl-[1,2,3]triazolo[1,5-a]pyridine;3-methyltriazolo[1,5-a]pyridine;

Chemical Property of 3-METHYL-1,2,3-TRIAZOLO(1,5-A)PYRIDINE

Chemical Property:

• Melting Point: 84-85 °C
• Refractive Index: 1.658
• PKA: 1.94±0.30(Predicted)
• PSA: 30.19000
• Density: 1.24 g/cm³
• LogP: 1.03770

Purity/Quality:

97% ^*data from raw suppliers

3-Methyl[1,2,3]triazolo[1,5-a]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 5-36/37/38
• Safety Statements: 15-26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-METHYL-1,2,3-TRIAZOLO(1,5-A)PYRIDINE

There total 25 articles about 3-METHYL-1,2,3-TRIAZOLO(1,5-A)PYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(E)-2-(1-hydrazineylideneethyl)pyridine (59742-91-5) → 3-methyl-[1,2,3]triazolo[1,5-a]pyridine (54856-82-5)

Guidance literature:

With [bis(acetoxy)iodo]benzene; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1080/00397910008087337

Reference yield: 85.0%

7-(3-methyl-[1,2,3]triazolo[1,5-a]pyridyl)boronic acid (726666-27-9) → 3-methyl-[1,2,3]triazolo[1,5-a]pyridine (54856-82-5)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; para-iodoanisole; potassium carbonate; In 1,2-dimethoxyethane; at 80 ℃;

DOI:10.1016/j.tet.2004.03.083

Reference yield: 83.0%

2-acetylpyridine hydrazone (59742-91-5) → 3-methyl-[1,2,3]triazolo[1,5-a]pyridine (54856-82-5)

Guidance literature:

With mesoporous silica-anchored with N-(3-(methoxysilyl))propyl group bidentate 2-aminoethylaminocopper(II) complex [MCM-41-2N-Cu(OAc)2]; In ethyl acetate; at 20 ℃; for 0.5h;

DOI:10.1055/s-0037-1610726

upstream raw materials:

(E)-2-(1-hydrazineylideneethyl)pyridine

methyl methacrylate

C₁₅H₁₃N₃O

3-methyl-7-trimethylsilyltriazolopyridine

Downstream raw materials:

3-Methyl-2-(1-methyl-2-oxo-2-phenyl-ethyl)-[1,2,3]triazolo[1,5-a]pyridin-2-ium; bromide

3-Methyl-2-(2-oxo-2-phenyl-ethyl)-[1,2,3]triazolo[1,5-a]pyridin-2-ium; bromide

2-acetylpyridine

1-(pyridine-2-yl)ethanol