2H-1,3-Diazepin-2-one, hexahydro-5,6-dihydroxy-4,7-bis[(4-methoxyphenyl)methyl]-1,3-bis(phen ylmethyl)-, (4R,5S,6S,7R)-

Base Information

Chemical Name:2H-1,3-Diazepin-2-one, hexahydro-5,6-dihydroxy-4,7-bis[(4-methoxyphenyl)methyl]-1,3-bis(phen ylmethyl)-, (4R,5S,6S,7R)-
CAS No.:167827-16-9
Molecular Formula:C35H38N2O5
Molecular Weight:566.697
Hs Code.:
Mol file:167827-16-9.mol

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2H-1,3-Diazepin-2-one, hexahydro-5,6-dihydroxy-4,7-bis[(4-methoxyphenyl)methyl]-1,3-bis(phen ylmethyl)-, (4R,5S,6S,7R)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2H-1,3-Diazepin-2-one, hexahydro-5,6-dihydroxy-4,7-bis[(4-methoxyphenyl)methyl]-1,3-bis(phen ylmethyl)-, (4R,5S,6S,7R)-

There total 10 articles about 2H-1,3-Diazepin-2-one, hexahydro-5,6-dihydroxy-4,7-bis[(4-methoxyphenyl)methyl]-1,3-bis(phen ylmethyl)-, (4R,5S,6S,7R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 207129-57-5
(3aS,4R,8R,8aS)-5,7-Dibenzyl-4,8-bis-(4-methoxy-benzyl)-2,2-dimethyl-hexahydro-1,3-dioxa-5,7-diaza-azulen-6-one

: 167827-16-9
(4R,5S,6S,7R)-1,3-Dibenzyl-5,6-dihydroxy-4,7-bis-(4-methoxy-benzyl)-[1,3]diazepan-2-one

Guidance literature:: With hydrogenchloride; In acetonitrile; for 2h; Ambient temperature;
DOI:10.1021/jm960083n

Reference yield:

: 207129-50-8
(4R,5S,6S,7R)-1,3-Dibenzyl-4,7-bis-(4-methoxy-benzyl)-5,6-bis-(2-trimethylsilanyl-ethoxymethoxy)-[1,3]diazepan-2-one

: 167827-16-9
(4R,5S,6S,7R)-1,3-Dibenzyl-5,6-dihydroxy-4,7-bis-(4-methoxy-benzyl)-[1,3]diazepan-2-one

Guidance literature:: With hydrogenchloride; In methanol; diethyl ether; at 25 ℃; for 0.25h;
DOI:10.1016/S0960-894X(98)00119-X

Reference yield:

: (R)-1-{(4S,5S)-5-[(R)-1-Amino-2-(4-methoxy-phenyl)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-2-(4-methoxy-phenyl)-ethylamine

: 167827-16-9
(4R,5S,6S,7R)-1,3-Dibenzyl-5,6-dihydroxy-4,7-bis-(4-methoxy-benzyl)-[1,3]diazepan-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) tetrachloroethane, 15 min, 2.) tetrachloroethane, reflux, 15 min

2: 1.) NaH / 1.) DMF, RT, 5 min, 2.) DMF, RT, 2 h

3: 20percent methanolic HCl / acetonitrile / 2 h / Ambient temperature

With hydrogenchloride; sodium hydride; In acetonitrile;
DOI:10.1021/jm960083n