N~4~-(6-ethoxy-3-methylquinolin-4-yl)-N~1~,N~1~-diethylpentane-1,4-diamine

Base Information

• Chemical Name: N~4~-(6-ethoxy-3-methylquinolin-4-yl)-N~1~,N~1~-diethylpentane-1,4-diamine
• CAS No.: 7498-96-6
• Molecular Formula: C₂₁H₃₃N₃O
• Molecular Weight: 343.513
• Mol file: 7498-96-6.mol

Synonyms:Quinoline,4-[(4-diethylamino-1-methylbutyl)amino]-6-ethoxy-3-methyl- (6CI); NSC 407505

Chemical Property of N~4~-(6-ethoxy-3-methylquinolin-4-yl)-N~1~,N~1~-diethylpentane-1,4-diamine

Chemical Property:

• Vapor Pressure: 8.11E-10mmHg at 25°C
• Boiling Point: 491.8°C at 760 mmHg
• Flash Point: 251.2°C
• Density: 1.032g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N~4~-(6-ethoxy-3-methylquinolin-4-yl)-N~1~,N~1~-diethylpentane-1,4-diamine

There total 4 articles about N~4~-(6-ethoxy-3-methylquinolin-4-yl)-N~1~,N~1~-diethylpentane-1,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-ethoxy-4-chloro-3-methyl-quinoline (861038-71-3) + 5-diethylamino-2-pentylamine (140-80-7) → N1-(6-ethoxy-3-methyl-[4]quinolyl)-N4,N4-diethyl-1-methyl-butanediyldiamine (7498-96-6)

Guidance literature:

With sodium iodide; phenol; at 165 - 175 ℃;

DOI:10.1021/ja01205a042

Reference yield:

6-ethoxy-3-methyl-quinolin-4-ol (860501-19-5,855870-93-8) → N1-(6-ethoxy-3-methyl-[4]quinolyl)-N4,N4-diethyl-1-methyl-butanediyldiamine (7498-96-6)

Guidance literature:

Multi-step reaction with 2 steps

1: phosphoryl chloride

2: NaI; phenol / 165 - 175 °C

With sodium iodide; trichlorophosphate; phenol;

DOI:10.1021/ja01205a042

Reference yield:

6-ethoxy-4-hydroxy-3-methyl-quinoline-2-carboxylic acid (709024-30-6) → N1-(6-ethoxy-3-methyl-[4]quinolyl)-N4,N4-diethyl-1-methyl-butanediyldiamine (7498-96-6)

Guidance literature:

Multi-step reaction with 3 steps

1: mineral oil / 270 - 280 °C

2: phosphoryl chloride

3: NaI; phenol / 165 - 175 °C

With sodium iodide; mineral oil; trichlorophosphate; phenol;

DOI:10.1021/ja01205a042

upstream raw materials:

6-ethoxy-4-chloro-3-methyl-quinoline

5-diethylamino-2-pentylamine

6-ethoxy-3-methyl-quinolin-4-ol

6-ethoxy-4-hydroxy-3-methyl-quinoline-2-carboxylic acid