Phosphonic acid, (aminophenylmethyl)-, diethyl ester

Base Information

• Chemical Name: Phosphonic acid, (aminophenylmethyl)-, diethyl ester
• CAS No.: 16814-08-7
• Molecular Formula: C₁₁H₁₈NO₃P
• Molecular Weight: 243.243
• Mol file: 16814-08-7.mol

Synonyms:

Chemical Property of Phosphonic acid, (aminophenylmethyl)-, diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phosphonic acid, (aminophenylmethyl)-, diethyl ester

There total 51 articles about Phosphonic acid, (aminophenylmethyl)-, diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

diethyl 1-(N-benzylamino)-1-phenylmethylphosphonate (63000-01-1) → diethyl 1-aminophenylmethylphosphonate (16814-08-7,42077-95-2,42077-97-4)

Guidance literature:

With formic acid; palladium hydroxide, 20 wt% on carbon; In methanol; for 2h; Inert atmosphere;

DOI:10.1021/jm500629e

Reference yield: 99.0%

C14H26NO3PSi (890151-94-7) → diethyl 1-aminophenylmethylphosphonate (16814-08-7,42077-95-2,42077-97-4)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1016/j.tetlet.2012.05.068

Reference yield: 98.0%

(Nitro-phenyl-methyl)-phosphonic acid diethyl ester (143023-69-2) → diethyl 1-aminophenylmethylphosphonate (16814-08-7,42077-95-2,42077-97-4)

Guidance literature:

With lithium borohydride; chloro-trimethyl-silane; In tetrahydrofuran; at 20 ℃;

DOI:10.1080/10426509608046403

upstream raw materials:

benzaldehyde

phosphonic acid diethyl ester

triethylamine

hydrobenzamide

Downstream raw materials:

N-<α-(diethoxyphosphinyl)benzyl>-N'-phenylurea

diethyl (4-methylphenylsulfonamido)(phenyl)methylphosphonate

<1-(tert-Butyloxycarbonyl-L-alanyl-amino)-1-phenyl>methylphosphonate de diethyle

diethyl benzimidoyl>phosphonate

Refernces

Synthesis, photopolymerization, and adhesive properties of hydrolytically stable phosphonic acid-containing (meth)acrylamides

10.1002/pola.27025

The research focuses on the synthesis, characterization, and evaluation of three novel dental monomers containing phosphonic acid groups, namely 1a, 2a, and 3a, for their potential use in dental adhesives. The purpose of this study was to develop monomers that exhibit hydrolytic stability, good polymerization rates, and strong adhesive properties. The researchers synthesized these monomers through a two-step process involving the reaction of α-aminophosphonates with acryloyl chloride or methacryloyl chloride, followed by hydrolysis using trimethylsilyl bromide. The synthesized monomers were characterized using various spectroscopic techniques, and their interactions with hydroxyapatite (HAP) were investigated. The study concluded that these phosphonic acid-containing (meth)acrylamides constitute a new class of monomers suitable for dental adhesives due to their hydrolytic stability, good polymerization rates, and adhesive properties. Key chemicals used in the synthesis process included diethyl amino(phenyl)methylphosphonate, diethyl 1-aminoheptylphosphonate, acryloyl chloride, methacryloyl chloride, trimethylsilyl bromide, and various solvents and reagents for purification and characterization.