2-(1-hydroxyethyl)cyclohexanol

Base Information

• Chemical Name: 2-(1-hydroxyethyl)cyclohexanol
• CAS No.: 24337-52-8
• Molecular Formula: C8H16 O2
• Molecular Weight: 144.214
• Mol file: 24337-52-8.mol

Synonyms:NSC84224

Chemical Property of 2-(1-hydroxyethyl)cyclohexanol

Chemical Property:

• Vapor Pressure: 0.00137mmHg at 25°C
• Boiling Point: 264.3°C at 760 mmHg
• Flash Point: 125.3°C
• Density: 1.056g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(1-hydroxyethyl)cyclohexanol

There total 11 articles about 2-(1-hydroxyethyl)cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.7%

2-acetylcyclohexanone (874-23-7,125117-37-5) → 2-(1-hydroxyethyl)cyclohexanol (24337-52-8,60713-86-2)

Guidance literature:

With sodium tetrahydroborate; water; sodium hydroxide; In ethanol; at 20 ℃; for 3h; Cooling with ice;

Reference yield:

cyclohexene-1-carboxylic acid (636-82-8) → (1S,2R)-2-((R)-1-Hydroxy-ethyl)-cyclohexanol (24337-52-8,104011-85-0,104011-86-1,108647-02-5,108647-05-8,60713-86-2)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether / 0 °C

2: 1.) t-hexylborane; 2.) H₂O₂, HO^(1-) / 1.) THF, reflux

With t-hexylborane; hydroxide; dihydrogen peroxide; In diethyl ether;

DOI:10.1016/S0040-4039(00)94276-X

Reference yield:

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → 2-(1-hydroxyethyl)cyclohexanol (24337-52-8,60713-86-2)

Guidance literature:

Multi-step reaction with 4 steps

1: cyclohexane / 65 - 70 °C / Reflux; Dean Stark apparatus

2: triethylamine / toluene / 20 - 35 °C

3: hydrogenchloride; water / toluene / 1 h / Reflux

4: ethanol; sodium tetrahydroborate / 10 - 15 °C

With hydrogenchloride; sodium tetrahydroborate; ethanol; water; triethylamine; In cyclohexane; toluene;

upstream raw materials:

2-acetylcyclohexanone

cyclohexanone

4-cyclohexen-1-ylmorpholine

(Z)-2-ethylidenecyclohexanol

Downstream raw materials:

2-chloro-4-methyl-hexahydro-benzo[1,3,2]dioxaphosphorin-2-sulfide

Refernces

• 1、 -. "New bicyclic dioxanes, their preparation and their use as organoleptic compounds". Page/Page column 10. . Retrieved 2011/04/14.
• 2、 Fernandez, Francys E.,Puerta, M. Carmen,Valerga, Pedro. "Half-sandwich ruthenium(ii) picolyl-nhc complexes: Synthesis, characterization, and catalytic activity in transfer hydrogenation reactions". experimental part. p. 5793 - 5802. Retrieved 2012/01/14.