2-(Aminomethyl)quinoline-8-ol

Base Information

• Chemical Name: 2-(Aminomethyl)quinoline-8-ol
• CAS No.: 17018-81-4
• Molecular Formula: C10H10N2O
• Molecular Weight: 174.19900
• Hs Code.: 2933499090
• Mol file: 17018-81-4.mol

Synonyms:8-hydroxy-2-quinolinemethylamine;2-Aminomethyl-8-chinolinol;2-aminomethyl-8-hydroxyquinoline;8-hydroxy-2-quinilinemethylamine;2-aminomethyl-quinolin-8-ol;

Chemical Property of 2-(Aminomethyl)quinoline-8-ol

Chemical Property:

• Boiling Point: 363.1±27.0 °C(Predicted)
• PKA: 7.20±0.40(Predicted)
• PSA: 59.14000
• Density: 1.288±0.06 g/cm3(Predicted)
• LogP: 2.09940

Purity/Quality:

98%min ^*data from raw suppliers

2-(aminomethyl)quinolin-8-ol 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(Aminomethyl)quinoline-8-ol

There total 3 articles about 2-(Aminomethyl)quinoline-8-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

8-hydroxyquinoline-2-carbaldehyde oxime (5603-22-5) → 2-aminomethyl-8-hydroxyquinoline (17018-81-4)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 4h;

Reference yield: 65.0%

8-hydroxyquinoline-2-carbonitrile (6759-78-0) → 2-aminomethyl-8-hydroxyquinoline (17018-81-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In acetic acid; for 14h; under 760.051 Torr;

DOI:10.1016/j.tetlet.2007.11.047

Reference yield:

2-hydroxymethyl-8-hydroxyquinoline (17018-82-5) → 2-aminomethyl-8-hydroxyquinoline (17018-81-4)

Guidance literature:

2-hydroxymethyl-8-hydroxyquinoline; With ferrous(II) sulfate heptahydrate; In acetonitrile; for 0.166667h;

With ammonium hydroxide; In acetonitrile; at 120 ℃; for 1h; Autoclave;

DOI:10.1021/acs.inorgchem.7b01190

upstream raw materials:

8-hydroxyquinoline-2-carbaldehyde oxime

8-hydroxyquinoline-2-carbonitrile

2-hydroxymethyl-8-hydroxyquinoline