3-[4-[(2-Methyl-1H-imidazo[4,5-c]pyridin-1-yl)methyl]benzoyl]-6-(4-fluorophenyl)-1H-indole

Base Information

Chemical Name:3-[4-[(2-Methyl-1H-imidazo[4,5-c]pyridin-1-yl)methyl]benzoyl]-6-(4-fluorophenyl)-1H-indole
CAS No.:170497-68-4
Molecular Formula:C29H21FN4O
Molecular Weight:460.51
Hs Code.:
DSSTox Substance ID:DTXSID601112787
Nikkaji Number:J925.762D
ChEMBL ID:CHEMBL174454

Synonyms:CHEMBL174454;SCHEMBL7494864;DTXSID601112787;BDBM50062103;[6-(4-Fluoro-phenyl)-1H-indol-3-yl]-[4-(2-methyl-imidazo[4,5-c]pyridin-1-ylmethyl)-phenyl]-methanone;[6-(4-Fluorophenyl)-1H-indol-3-yl][4-[(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)methyl]phenyl]methanone;170497-68-4;3-[4-[(2-Methyl-1H-imidazo[4,5-c]pyridin-1-yl)methyl]benzoyl]-6-(4-fluorophenyl)-1H-indole

Suppliers and Price of 3-[4-[(2-Methyl-1H-imidazo[4,5-c]pyridin-1-yl)methyl]benzoyl]-6-(4-fluorophenyl)-1H-indole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-[4-[(2-Methyl-1H-imidazo[4,5-c]pyridin-1-yl)methyl]benzoyl]-6-(4-fluorophenyl)-1H-indole

Chemical Property:

XLogP3:5.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:460.16993947
Heavy Atom Count:35
Complexity:734

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=NC2=C(N1CC3=CC=C(C=C3)C(=O)C4=CNC5=C4C=CC(=C5)C6=CC=C(C=C6)F)C=CN=C2

Technology Process of 3-[4-[(2-Methyl-1H-imidazo[4,5-c]pyridin-1-yl)methyl]benzoyl]-6-(4-fluorophenyl)-1H-indole

There total 5 articles about 3-[4-[(2-Methyl-1H-imidazo[4,5-c]pyridin-1-yl)methyl]benzoyl]-6-(4-fluorophenyl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 170497-69-5
1-N,N-dimethylcarbamoyl-6-(4-fluorophenyl)-3-{4-[(1H-2-methylimidazo[4.5-c]pyrid-1-yl)methyl]benzoyl}indole

: 170497-68-4
6-(4-fluorophenyl)-3-{4-[(1H-2-methylimidazo[4.5-c]pyrid-1-yl)methyl]benzoyl}indole

Guidance literature:: With sodium hydroxide; In methanol; at 0 ℃; for 1h;
DOI:10.1021/jm970389+

Reference yield:

: 876-08-4
p-(chloromethyl)benzoyl chloride

: 170497-68-4
6-(4-fluorophenyl)-3-{4-[(1H-2-methylimidazo[4.5-c]pyrid-1-yl)methyl]benzoyl}indole

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) AlCl₃ / 1.) CH₂Cl₂, RT, 15 min, 2.) CH₂Cl₂, RT, 2.5 h

2: 1.) NaBr, 2.) DMPU / 1.) THF, RT, 1 h, 2.) THF, RT, 3 h

3: 1 M aq. NaOH / methanol / 1 h / 0 °C

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; sodium hydroxide; aluminium trichloride; sodium bromide; In methanol;
DOI:10.1021/jm970389+

Reference yield:

: 147621-16-7
6-(4-fluorophenyl)-1H-indole

: 170497-68-4
6-(4-fluorophenyl)-3-{4-[(1H-2-methylimidazo[4.5-c]pyrid-1-yl)methyl]benzoyl}indole

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) KOH / 1.) THF, RT, 15 min, 2.) THF, RT, 4 h

2: 1.) AlCl₃ / 1.) CH₂Cl₂, RT, 15 min, 2.) CH₂Cl₂, RT, 2.5 h

3: 1.) NaBr, 2.) DMPU / 1.) THF, RT, 1 h, 2.) THF, RT, 3 h

4: 1 M aq. NaOH / methanol / 1 h / 0 °C

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; potassium hydroxide; sodium hydroxide; aluminium trichloride; sodium bromide; In methanol;
DOI:10.1021/jm970389+