trans-2-(3-methylphenyl)-3-oxo-1-cyclohexaneacetic acid

Base Information

• Chemical Name: trans-2-(3-methylphenyl)-3-oxo-1-cyclohexaneacetic acid
• CAS No.: 108299-76-9
• Molecular Formula: C₁₅H₁₈O₃
• Molecular Weight: 246.306
• Mol file: 108299-76-9.mol

Synonyms:

Chemical Property of trans-2-(3-methylphenyl)-3-oxo-1-cyclohexaneacetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-2-(3-methylphenyl)-3-oxo-1-cyclohexaneacetic acid

There total 2 articles about trans-2-(3-methylphenyl)-3-oxo-1-cyclohexaneacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(3-methylphenyl)-2-cyclohexenone oxime (90735-88-9,106213-92-7) → trans-2-(3-methylphenyl)-3-oxo-1-cyclohexaneacetic acid (108299-76-9)

Guidance literature:

Multi-step reaction with 2 steps

1: aqueous HCl

2: potassium tert-butylate; tert-butanol / Erwaermen des Reaktionsprodukts mit Naphthalin-2-sulfonsaeure in Benzol

With hydrogenchloride; potassium tert-butylate; tert-butyl alcohol;

DOI:10.1039/jr9590001727

Reference yield:

t-butyl malonate (541-16-2) + 2-(3-methylphenyl)-2-cyclohexenone (107388-44-3) → trans-2-(3-methylphenyl)-3-oxo-1-cyclohexaneacetic acid (108299-76-9)

Guidance literature:

With potassium tert-butylate; tert-butyl alcohol; Erwaermen des Reaktionsprodukts mit Naphthalin-2-sulfonsaeure in Benzol;

DOI:10.1039/jr9590001727

upstream raw materials:

t-butyl malonate

2-(3-methylphenyl)-2-cyclohexenone

2-(3-methylphenyl)-2-cyclohexenone oxime