2-Propenoic acid, 3-[4-[(2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl]phenyl]- 3-(2-fluorophenyl)-, ethyl ester

Base Information

Chemical Name:2-Propenoic acid, 3-[4-[(2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl]phenyl]- 3-(2-fluorophenyl)-, ethyl ester
CAS No.:170790-10-0
Molecular Formula:C28H28FN3O2
Molecular Weight:457.548
Hs Code.:
Mol file:170790-10-0.mol

Synonyms:

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Chemical Property of 2-Propenoic acid, 3-[4-[(2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl]phenyl]- 3-(2-fluorophenyl)-, ethyl ester

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Technology Process of 2-Propenoic acid, 3-[4-[(2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl]phenyl]- 3-(2-fluorophenyl)-, ethyl ester

There total 4 articles about 2-Propenoic acid, 3-[4-[(2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl]phenyl]- 3-(2-fluorophenyl)-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 106-38-7
para-bromotoluene

: 170790-10-0
(E)-3-[4-(2-Ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-ylmethyl)-phenyl]-3-(2-fluoro-phenyl)-acrylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) magnesium, 3.) 1N aq. HCl

2: 1.) NaH / 1.) dimethoxyethane, RT, 30 min, 2.) dimethoxyethane, reflux, 4 d

3: N-bromosuccinimide, benzoyl peroxide / CCl₄ / 3 h / Heating

4: 1.) NaH / 1.) DMF, 15 min, 2.) DMF, RT, overnight

With hydrogenchloride; N-Bromosuccinimide; Perbenzoic acid; sodium hydride; magnesium; In tetrachloromethane;
DOI:10.1021/jm9508853

Reference yield:

: 394-47-8
2-fluorobenzonitrile

: 170790-10-0
(E)-3-[4-(2-Ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-ylmethyl)-phenyl]-3-(2-fluoro-phenyl)-acrylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) magnesium, 3.) 1N aq. HCl

2: 1.) NaH / 1.) dimethoxyethane, RT, 30 min, 2.) dimethoxyethane, reflux, 4 d

3: N-bromosuccinimide, benzoyl peroxide / CCl₄ / 3 h / Heating

4: 1.) NaH / 1.) DMF, 15 min, 2.) DMF, RT, overnight

With hydrogenchloride; N-Bromosuccinimide; Perbenzoic acid; sodium hydride; magnesium; In tetrachloromethane;
DOI:10.1021/jm9508853

Reference yield:

: 68295-43-2
(2-fluorophenyl)(p-tolyl)methanone

: 170790-10-0
(E)-3-[4-(2-Ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-ylmethyl)-phenyl]-3-(2-fluoro-phenyl)-acrylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) dimethoxyethane, RT, 30 min, 2.) dimethoxyethane, reflux, 4 d

2: N-bromosuccinimide, benzoyl peroxide / CCl₄ / 3 h / Heating

3: 1.) NaH / 1.) DMF, 15 min, 2.) DMF, RT, overnight

With N-Bromosuccinimide; Perbenzoic acid; sodium hydride; In tetrachloromethane;
DOI:10.1021/jm9508853