2-benzyl-6-hydroxy-3(2H)-pyridazinone

Base Information

• Chemical Name: 2-benzyl-6-hydroxy-3(2H)-pyridazinone
• CAS No.: 1708-46-9
• Molecular Formula: C11H10N2O2
• Molecular Weight: 202.213
• European Community (EC) Number: 829-374-0
• DSSTox Substance ID: DTXSID20350574
• Wikidata: Q82126598
• Mol file: 1708-46-9.mol

Synonyms:1708-46-9;2-benzyl-1H-pyridazine-3,6-dione;2-benzyl-6-hydroxy-3(2H)-pyridazinone;1-benzyl-1,2-dihydropyridazine-3,6-dione;1-Benzyl-1,2,3,6-tetrahydropyridazine-3,6-dione;2-benzyl-6-hydroxypyridazin-3-one;starbld0037634;Oprea1_865414;SCHEMBL6133942;SCHEMBL21055329;DTXSID20350574;HMS1653N13;BAA70846;STK974120;STL020466;AKOS002312188;2-benzyl-6-hydroxypyridazin-3(2H)-one;CS-0256522;EN300-6494515;SR-01000013110;SR-01000013110-1;Z57347465

Chemical Property of 2-benzyl-6-hydroxy-3(2H)-pyridazinone

Chemical Property:

• XLogP3: 0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 202.074227566
• Heavy Atom Count: 15
• Complexity: 293

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CN2C(=O)C=CC(=O)N2

Technology Process of 2-benzyl-6-hydroxy-3(2H)-pyridazinone

There total 5 articles about 2-benzyl-6-hydroxy-3(2H)-pyridazinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

maleic anhydride (108-31-6) + Benzylhydrazine (555-96-4) → 2-benzyl-6-hydroxypyridazin-3(2H)-one (1708-46-9)

Guidance literature:

With hydrogenchloride; In water; at 110 - 120 ℃; for 6h;

DOI:10.1177/1747519819866402

Reference yield:

2-[(1-benzyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy]acetohydrazide → 2-benzyl-6-hydroxypyridazin-3(2H)-one (1708-46-9)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / ethanol / 6 h / 80 °C

2: potassium hydroxide / water / Heating

With hydrogenchloride; potassium hydroxide; In ethanol; water;

DOI:10.1177/1747519819866402

Reference yield:

potassium (2-{2-[(1-benzyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy]acetyl}hydrazine-1-carbonothioyl)amide → 2-benzyl-6-hydroxypyridazin-3(2H)-one (1708-46-9)

Guidance literature:

With potassium hydroxide; In water; Heating;

DOI:10.1177/1747519819866402

upstream raw materials:

maleic anhydride

Benzylhydrazine