lecimibide

Base Information

• Chemical Name: lecimibide
• CAS No.: 130804-35-2
• Molecular Formula: C34H40 F2 N4 O S
• Molecular Weight: 590.781
• Mol file: 130804-35-2.mol

Synonyms:3-(2,4-Difluorophenyl)-1-[5-[(4,5-diphenylimidazol-2-yl)thio]pentyl]-1-heptylurea;DuP 128; Lecimibide

Chemical Property of lecimibide

Chemical Property:

• PSA: 89.81000
• Density: 1.21g/cm³
• LogP: 9.80240

Purity/Quality:

95% ^*data from raw suppliers

LECIMIBIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Antihyperlipidemic.

Technology Process of lecimibide

There total 10 articles about lecimibide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2,4-diflurophenylisocyanate (59025-55-7) + N-[5-(4,5-diphenyl-1H-imidazol-2-ylthio)pentyl]-1-heptanamine (136445-76-6) → N'-(2,4-difluorophenyl)-N-[5-(4,5-diphenyl-1H-imidazol-2-ylthio)pentyl]-N-heptylurea (130804-35-2)

Guidance literature:

In hexane; for 3h; Ambient temperature;

DOI:10.1021/jm00047a009

Reference yield:

1-Heptylamine (111-68-2) → N'-(2,4-difluorophenyl)-N-[5-(4,5-diphenyl-1H-imidazol-2-ylthio)pentyl]-N-heptylurea (130804-35-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 78 percent / toluene / 18 h / Heating

2: 85 percent / LiAlH₄ / tetrahydrofuran / 18 h / Heating

3: 97 percent / CH₂Cl₂ / 1 h

4: 99 percent / Ph₃P, CBr₄ / CH₂Cl₂ / 3 h / Ambient temperature

5: 1.) NaH / 1.) DMF, 2 h, 2.) DMF, RT, 2 h

With lithium aluminium tetrahydride; carbon tetrabromide; sodium hydride; triphenylphosphine; In tetrahydrofuran; dichloromethane; toluene;

DOI:10.1021/jm00047a009

Reference yield:

3,4,5,6-tetrahydro-2H-pyran-2-one (542-28-9,26354-94-9) → N'-(2,4-difluorophenyl)-N-[5-(4,5-diphenyl-1H-imidazol-2-ylthio)pentyl]-N-heptylurea (130804-35-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 78 percent / toluene / 18 h / Heating

2: 85 percent / LiAlH₄ / tetrahydrofuran / 18 h / Heating

3: 97 percent / CH₂Cl₂ / 1 h

4: 99 percent / Ph₃P, CBr₄ / CH₂Cl₂ / 3 h / Ambient temperature

5: 1.) NaH / 1.) DMF, 2 h, 2.) DMF, RT, 2 h

With lithium aluminium tetrahydride; carbon tetrabromide; sodium hydride; triphenylphosphine; In tetrahydrofuran; dichloromethane; toluene;

DOI:10.1021/jm00047a009

upstream raw materials:

2,4-diflurophenylisocyanate

N-[5-(4,5-diphenyl-1H-imidazol-2-ylthio)pentyl]-1-heptanamine

N-(2,4-difluorophenyl)-N'-heptyl-N'-(5-bromopentyl)urea

4,5-diphenyl-1H-imidazole-2-thiol