Acetic acid (2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-(hydroxy-{hydroxy-[2-(4-nitro-phenyl)-ethoxy]-phosphorylmethyl}-phosphinoyloxymethyl)-tetrahydro-furan-3-yl ester

Base Information

• Chemical Name: Acetic acid (2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-(hydroxy-{hydroxy-[2-(4-nitro-phenyl)-ethoxy]-phosphorylmethyl}-phosphinoyloxymethyl)-tetrahydro-furan-3-yl ester
• CAS No.: 203121-60-2
• Molecular Formula: C₂₇H₃₀N₄O₁₃P₂
• Molecular Weight: 680.502

Synonyms:

Chemical Property of Acetic acid (2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-(hydroxy-{hydroxy-[2-(4-nitro-phenyl)-ethoxy]-phosphorylmethyl}-phosphinoyloxymethyl)-tetrahydro-furan-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of Acetic acid (2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-(hydroxy-{hydroxy-[2-(4-nitro-phenyl)-ethoxy]-phosphorylmethyl}-phosphinoyloxymethyl)-tetrahydro-furan-3-yl ester

There total 3 articles about Acetic acid (2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-(hydroxy-{hydroxy-[2-(4-nitro-phenyl)-ethoxy]-phosphorylmethyl}-phosphinoyloxymethyl)-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-N-Benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine (67219-55-0) → Acetic acid (2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-(hydroxy-{hydroxy-[2-(4-nitro-phenyl)-ethoxy]-phosphorylmethyl}-phosphinoyloxymethyl)-tetrahydro-furan-3-yl ester (203121-60-2)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine

2: AcOH

3: 2.) H₂O

With pyridine; water; acetic acid;

DOI:10.1080/07328319808004723

Reference yield:

Acetic acid (2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester (102219-53-4) → Acetic acid (2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-(hydroxy-{hydroxy-[2-(4-nitro-phenyl)-ethoxy]-phosphorylmethyl}-phosphinoyloxymethyl)-tetrahydro-furan-3-yl ester (203121-60-2)

Guidance literature:

Multi-step reaction with 2 steps

1: AcOH

2: 2.) H₂O

With water; acetic acid;

DOI:10.1080/07328319808004723

Reference yield:

3,7-Bis-[2-(4-nitro-phenyl)-ethoxy]-2,6,9-trioxa-1,3,5,7-tetraphospha-bicyclo[3.3.1]nonane 1,3,5,7-tetraoxide (1025799-36-3) + (2R,3S,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-(hydroxymethyl)tetrahydrofuran-3-yl acetate (17182-39-7) → Acetic acid (2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-(hydroxy-{hydroxy-[2-(4-nitro-phenyl)-ethoxy]-phosphorylmethyl}-phosphinoyloxymethyl)-tetrahydro-furan-3-yl ester (203121-60-2)

Guidance literature:

With water; Yield given. Multistep reaction;

DOI:10.1080/07328319808004723

upstream raw materials:

3,7-Bis-[2-(4-nitro-phenyl)-ethoxy]-2,6,9-trioxa-1,3,5,7-tetraphospha-bicyclo[3.3.1]nonane 1,3,5,7-tetraoxide

(2R,3S,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-(hydroxymethyl)tetrahydrofuran-3-yl acetate

4-N-Benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine

Acetic acid (2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester

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