2-Methyl-3-phenylquinoline

Base Information

• Chemical Name: 2-Methyl-3-phenylquinoline
• CAS No.: 1721-91-1
• Molecular Formula: C16H13N
• Molecular Weight: 219.286
• DSSTox Substance ID: DTXSID80491351
• Nikkaji Number: J2.792.610J
• Wikidata: Q82335807

Synonyms:1721-91-1;2-Methyl-3-phenylquinoline;quinoline,2-methyl-3-phenyl-;SCHEMBL7071941;DTXSID80491351

Chemical Property of 2-Methyl-3-phenylquinoline

Chemical Property:

• XLogP3: 4.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 219.104799419
• Heavy Atom Count: 17
• Complexity: 244

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=NC2=CC=CC=C2C=C1C3=CC=CC=C3

Technology Process of 2-Methyl-3-phenylquinoline

There total 15 articles about 2-Methyl-3-phenylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

o-aminobenzaldehyde (529-23-7) + 1-phenyl-acetone (103-79-7,136675-26-8) → 2-methyl-3-phenylquinoline (1721-91-1)

Guidance literature:

With potassium hydroxide; In ethanol; for 2h; Heating;

Reference yield: 65.0%

1-Phenylprop-1-yne (673-32-5) + 2-Aminobenzyl alcohol (5344-90-1) → 2-methyl-3-phenylquinoline (1721-91-1)

Guidance literature:

With potassium hydroxide; In dimethyl sulfoxide; at 90 ℃; regioselective reaction; Inert atmosphere;

DOI:10.1021/acs.orglett.6b00817

Reference yield: 64.0%

2-methyl-1H-indole (95-20-5) + 3-chloro-3-phenyl-3H-diazirine (4460-46-2) → 2-methyl-3-phenylquinoline (1721-91-1)

Guidance literature:

With sodium carbonate; In acetonitrile; at 50 ℃; for 12h; Sealed tube;

DOI:10.1021/jacs.1c06287

upstream raw materials:

2-methyl-3-phenylquinoline-4-carboxylic acid

o-trans-Styrylthioacetanilide

o-aminobenzaldehyde

1-phenyl-acetone

Downstream raw materials:

(3-phenyl-[2]quinolyl)-pyruvic acid ethyl ester

1-methyl-4-phenylpyrrolo[1,2-a]quinoline

3-phenyl-2-vinylquinoline

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