Glycine, N-[[4-[[4-(1,1-dimethylethyl)benzoyl]amino]-2-oxo-1(2H)-pyrimidinyl]acet yl]-N-[2-[[(4-methoxyphenyl)diphenylmethyl]amino]ethyl]-, methyl ester

Base Information

Chemical Name:Glycine, N-[[4-[[4-(1,1-dimethylethyl)benzoyl]amino]-2-oxo-1(2H)-pyrimidinyl]acet yl]-N-[2-[[(4-methoxyphenyl)diphenylmethyl]amino]ethyl]-, methyl ester
CAS No.:172405-42-4
Molecular Formula:C42H45N5O6
Molecular Weight:715.849
Hs Code.:

Glycine,
N-[[4-[[4-(1,1-dimethylethyl)benzoyl]amino]-2-oxo-1(2H)-pyrimidinyl]acet
yl]-N-[2-[[(4-methoxyphenyl)diphenylmethyl]amino]ethyl]-, methyl ester

Synonyms:

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Chemical Property of Glycine, N-[[4-[[4-(1,1-dimethylethyl)benzoyl]amino]-2-oxo-1(2H)-pyrimidinyl]acet yl]-N-[2-[[(4-methoxyphenyl)diphenylmethyl]amino]ethyl]-, methyl ester

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Technology Process of Glycine, N-[[4-[[4-(1,1-dimethylethyl)benzoyl]amino]-2-oxo-1(2H)-pyrimidinyl]acet yl]-N-[2-[[(4-methoxyphenyl)diphenylmethyl]amino]ethyl]-, methyl ester

There total 6 articles about Glycine, N-[[4-[[4-(1,1-dimethylethyl)benzoyl]amino]-2-oxo-1(2H)-pyrimidinyl]acet yl]-N-[2-[[(4-methoxyphenyl)diphenylmethyl]amino]ethyl]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 172405-12-8
1-(carboxymethyl)-N⁴-(4-tert-butylbenzoyl)cytosine

: 172405-21-9
methyl N-<2-((4-methoxyphenyl)-diphenylmethyl)aminoethyl> glycinate

: 172405-42-4
methyl N-<2-((4-methoxyphenyl)-diphenylmethylamino)ethyl>-N-<(N⁴-(4-tert-butylbenzoyl)-cytosin-1-yl)acetyl> glycinate

Guidance literature:: With N-Ethylmaleimide; bis-2-propyl carbonate; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; In N,N-dimethyl-formamide; for 20h; Ambient temperature;
DOI:10.1016/0040-4020(95)00766-2

Reference yield:

: 135697-25-5
4-(1,1-Dimethylethyl)-N-[1,2-dihydro-2-oxo-4-pyrimidinyl]benzamide

: 172405-42-4
methyl N-<2-((4-methoxyphenyl)-diphenylmethylamino)ethyl>-N-<(N⁴-(4-tert-butylbenzoyl)-cytosin-1-yl)acetyl> glycinate

Guidance literature:: Multi-step reaction with 3 steps

1: 42 percent / NaH / dimethylformamide / 1 h / Ambient temperature

2: 86 percent / 2N aq. NaOH / dioxane; H₂O / Ambient temperature

3: 92 percent / HOOBt, NEM, DIPC / dimethylformamide / 20 h / Ambient temperature

With N-Ethylmaleimide; sodium hydroxide; bis-2-propyl carbonate; sodium hydride; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1016/0040-4020(95)00766-2

Reference yield:

: N-(2-aminoethyl)glycine methyl ester dihydrochloride

: 172405-42-4
methyl N-<2-((4-methoxyphenyl)-diphenylmethylamino)ethyl>-N-<(N⁴-(4-tert-butylbenzoyl)-cytosin-1-yl)acetyl> glycinate

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / NEt₃ / dimethylformamide; CH₂Cl₂ / 2.5 h / Ambient temperature

2: 92 percent / HOOBt, NEM, DIPC / dimethylformamide / 20 h / Ambient temperature

With N-Ethylmaleimide; bis-2-propyl carbonate; triethylamine; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/0040-4020(95)00766-2