2-(pyridin-4-yl)-1H-benzo[d]imidazol-6-amine

Base Information

• Chemical Name: 2-(pyridin-4-yl)-1H-benzo[d]imidazol-6-amine
• CAS No.: 1724-67-0
• Molecular Formula: C12H10N4
• Molecular Weight: 210.238
• Mol file: 1724-67-0.mol

Synonyms:2'-deoxy-6-azacytidine;6-Aza-2'-deoxy-cytidin;2-pyridin-4-yl-1H-benzoimidazol-5-ylamine;Aza-2'-desoxy-cytidin;6-Aza-2'-desoxy-cytidin;5-Amino-2-<4-pyridyl>-benzimidazol;

Chemical Property of 2-(pyridin-4-yl)-1H-benzo[d]imidazol-6-amine

Chemical Property:

• PSA: 67.59000
• LogP: 2.78830

Purity/Quality:

97% ^*data from raw suppliers

2-(PYRIDIN-4-YL)-1H-1,3-BENZODIAZOL-5-AMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(pyridin-4-yl)-1H-benzo[d]imidazol-6-amine

There total 7 articles about 2-(pyridin-4-yl)-1H-benzo[d]imidazol-6-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.4%

5-nitro-2-(pyridine-4-yl)-1H-benzo[d]imidazole (148533-73-7) → 2-(pyridin-4-yl)-1H-benzo[d]imidazole-5-amine (1724-67-0)

Guidance literature:

With calcium chloride; zinc; In ethanol; for 2h; Heating;

DOI:10.1007/BF02269539

Reference yield: 64.0%

→ 2-(pyridin-4-yl)-1H-benzo[d]imidazole-5-amine (1724-67-0)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; ethyl acetate; at 20 ℃; for 6h;

Reference yield:

pyridine-4-carboxylic acid (55-22-1) → 2-(pyridin-4-yl)-1H-benzo[d]imidazole-5-amine (1724-67-0)

Guidance literature:

Multi-step reaction with 3 steps

2: 97.5 percent / conc. nitric acid; conc. sulfuric acid / 2 h / 0 - 20 °C

3: 71.4 percent / Zn; aq. CaCl₂ / ethanol / 2 h / Heating

With sulfuric acid; nitric acid; calcium chloride; zinc; In ethanol; 1: Condensation / 2: Nitration / 3: Reduction;

DOI:10.1007/BF02269539

upstream raw materials:

5-nitro-2-(pyridine-4-yl)-1H-benzo[d]imidazole

pyridine-4-carboxylic acid

2-(pyridin-4-yl)-1H-benzo[d]imidazole

1,2-diamino-benzene

Downstream raw materials:

2-phenoxy-N-[(2-pyridin-4-yl)-1H-benzo[d]imidazole-5-yl]propionamide