Pyridazine, 3-[1-(1-anthracenyl)-2,2-dimethylpropoxy]-6-chloro-, (S)-

Base Information

• Chemical Name: Pyridazine, 3-[1-(1-anthracenyl)-2,2-dimethylpropoxy]-6-chloro-, (S)-
• CAS No.: 172787-84-7
• Molecular Formula: C23H21ClN2O
• Mol file: 172787-84-7.mol

Synonyms:

Chemical Property of Pyridazine, 3-[1-(1-anthracenyl)-2,2-dimethylpropoxy]-6-chloro-, (S)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Pyridazine, 3-[1-(1-anthracenyl)-2,2-dimethylpropoxy]-6-chloro-, (S)-

There total 4 articles about Pyridazine, 3-[1-(1-anthracenyl)-2,2-dimethylpropoxy]-6-chloro-, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

anthracene-1-carboxylic acid (607-42-1) → (S)-1-(1-anthryl)-2,2-dimethylprop-1-yl 6-chloro-3-pyridazyl ether (172787-84-7)

Guidance literature:

Multi-step reaction with 4 steps

1: oxalyl dichloride / CH₂Cl₂; tetrahydrofuran / 1 h / 23 °C

2: 1.) nBuLi, 2.) CuI, 3.) tBuLi

3: 1.) BH₃*DMS, CBS catalyst (from (S)-diphenylprolinol and n-butylboronic acid), 2.) HCl / 1.) toluene, 23 deg C, 12 h, 2.) MeOH, 30 min

4: 1.) KH / 1.) DME, 23 deg C, 20 min, 2.) DME, 23 deg C, 30 min

With hydrogenchloride; copper(l) iodide; n-butyllithium; oxalyl dichloride; dimethylsulfide borane complex; tert.-butyl lithium; potassium hydride; (S)-tetrahydro-1-butyl-3,3-diphenyl-1H,3H-pyrrolo{2,1-c}{1,3,2}oxazaborole; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ja00149a004

Reference yield:

1-anthracenecarbonyl chloride (42442-96-6) → (S)-1-(1-anthryl)-2,2-dimethylprop-1-yl 6-chloro-3-pyridazyl ether (172787-84-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) nBuLi, 2.) CuI, 3.) tBuLi

2: 1.) BH₃*DMS, CBS catalyst (from (S)-diphenylprolinol and n-butylboronic acid), 2.) HCl / 1.) toluene, 23 deg C, 12 h, 2.) MeOH, 30 min

3: 1.) KH / 1.) DME, 23 deg C, 20 min, 2.) DME, 23 deg C, 30 min

With hydrogenchloride; copper(l) iodide; n-butyllithium; dimethylsulfide borane complex; tert.-butyl lithium; potassium hydride; (S)-tetrahydro-1-butyl-3,3-diphenyl-1H,3H-pyrrolo{2,1-c}{1,3,2}oxazaborole;

DOI:10.1021/ja00149a004

Reference yield:

1-anthryl tert-butyl ketone (109690-73-5) → (S)-1-(1-anthryl)-2,2-dimethylprop-1-yl 6-chloro-3-pyridazyl ether (172787-84-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) BH₃*DMS, CBS catalyst (from (S)-diphenylprolinol and n-butylboronic acid), 2.) HCl / 1.) toluene, 23 deg C, 12 h, 2.) MeOH, 30 min

2: 1.) KH / 1.) DME, 23 deg C, 20 min, 2.) DME, 23 deg C, 30 min

With hydrogenchloride; dimethylsulfide borane complex; potassium hydride; (S)-tetrahydro-1-butyl-3,3-diphenyl-1H,3H-pyrrolo{2,1-c}{1,3,2}oxazaborole;

DOI:10.1021/ja00149a004

upstream raw materials:

3,6-dichlorpyridazine

(S)-1-anthryl-tert-butylcarbinol

anthracene-1-carboxylic acid

1-anthracenecarbonyl chloride