CYCLOHEXANE-1,1-DICARBOXYLIC ACID

Base Information

• Chemical Name: CYCLOHEXANE-1,1-DICARBOXYLIC ACID
• CAS No.: 1127-08-8
• Molecular Formula: C8H12 O4
• Molecular Weight: 172.181
• Hs Code.: 2917209090
• Mol file: 1127-08-8.mol

Synonyms:1,1-Cyclohexanedicarboxylate;Cyclopentamethylenemalonic acid

Chemical Property of CYCLOHEXANE-1,1-DICARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 1.13E-06mmHg at 25°C
• Melting Point: 175.5-176.5°C
• Boiling Point: 375.4°Cat760mmHg
• PKA: 4.61±0.20(Predicted)
• Flash Point: 195°C
• PSA: 74.60000
• Density: 1.33g/cm³
• LogP: 1.10610
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

Cyclohexane-1,1-dicarboxylic acid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi,T
• Statements: 25-36/37/38
• Safety Statements: 26-36/37-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of CYCLOHEXANE-1,1-DICARBOXYLIC ACID

There total 24 articles about CYCLOHEXANE-1,1-DICARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diethyl cyclohexane-1,1-dicarboxylate (1139-13-5) → cyclohexanedicarboxylic acid (1127-08-8)

Guidance literature:

With potassium hydroxide; Hydrolysis;

Reference yield:

cyclohexanylcarbonyl chloride (2719-27-9) + trichloromethyl chloroformate (503-38-8) → cyclohexanedicarboxylic acid (1127-08-8)

Guidance literature:

at 225 ℃; Behandeln des Reaktionsprodukts mit Wasser;

Reference yield:

1,5-dibromo-pentane (111-24-0) → cyclohexanedicarboxylic acid (1127-08-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 61 percent / EtONa / ethanol

2: NaOH; H₂O / 48 h / 20 °C

With sodium hydroxide; water; sodium ethanolate; In ethanol; 1: Alkylation / 2: Hydrolysis;

DOI:10.1016/S0022-1139(99)00233-X

upstream raw materials:

cyclohexane-1,1-dicarbonyl dichloride

diethyl cyclohexane-1,1-dicarboxylate

1,1-bis(hydroxymethyl)cyclohexane

dimethyl 1,1-cyclohexanedicarboxylate

Downstream raw materials:

(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl cyclohexanecarboxylate

N-benzylcyclohexanecarboxamide

N-phenylcyclohexanamide

1H-1,2,3-benzotriazol-1-yl(cyclohexyl)methanone

Refernces

• 1、 Dmowski, Wojciech,Wolniewicz, Adam. "Selective reactions of 1,1-cycloalkanedicarboxylic acids with SF4. a route to 1,1-bis(trifluoromethyl)cycloalkanes, 1-fluoroformyl-1-(trifluoromethyl)cycloalkanes and 1-(trifluoromethyl)-1-cycloalkanecarboxylic acids". . p. 141 - 146. Retrieved 2007/10/03.