(2R,4R)-2-Ethoxy-4-methyl-3,4-dihydro-2H-pyran

Base Information

• Chemical Name: (2R,4R)-2-Ethoxy-4-methyl-3,4-dihydro-2H-pyran
• CAS No.: 17322-76-8
• Molecular Formula: C8H14O2
• DSSTox Substance ID: DTXSID30499943
• Nikkaji Number: J771.441F
• Wikidata: Q82351201
• Mol file: 17322-76-8.mol

Synonyms:DTXSID30499943;17322-76-8;(2R,4R)-2-Ethoxy-4-methyl-3,4-dihydro-2H-pyran

Chemical Property of (2R,4R)-2-Ethoxy-4-methyl-3,4-dihydro-2H-pyran

Chemical Property:

• XLogP3: 1.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 142.099379685
• Heavy Atom Count: 10
• Complexity: 120

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1CC(C=CO1)C
• Isomeric SMILES: CCO[C@H]1C[C@H](C=CO1)C

Technology Process of (2R,4R)-2-Ethoxy-4-methyl-3,4-dihydro-2H-pyran

There total 3 articles about (2R,4R)-2-Ethoxy-4-methyl-3,4-dihydro-2H-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

trans-Crotonaldehyde (123-73-9,4170-30-3) + ethyl vinyl ether (109-92-2,25104-37-4) → (2R,4R)-2-Ethoxy-4-methyl-3,4-dihydro-2H-pyran (10138-44-0,17322-76-8,17322-77-9)

Guidance literature:

1,3,5-tris(1,1,1-trifluorohexane-2,4-dione-6-yl)benzene yttrium; for 72h;

DOI:10.1139/v96-195

Reference yield: 88.0%

ethyl vinyl ether (109-92-2,25104-37-4) + crotonaldehyde (123-73-9,4170-30-3) → (2R,4R)-2-Ethoxy-4-methyl-3,4-dihydro-2H-pyran (10138-44-0,17322-76-8,17322-77-9)

Guidance literature:

With (tris(6,6,7,7,8,8,8-heptafluoro-2,2-dimethyl-3,5-octadionato))ytterbium(III); at 45 - 100 ℃;

DOI:10.1016/j.tet.2009.04.013

Reference yield:

→ trans-2-Ethoxy-4-methyl-3,4-dihydro-2H-pyran (10138-44-0,17322-76-8,17322-77-9)

Guidance literature:

Crotonaldehyd, Ethylvinylether, Hydrochinon <Δ>;

upstream raw materials:

trans-Crotonaldehyde

ethyl vinyl ether

crotonaldehyde