1-Benzofuran-4-ylmethanol

Base Information

• Chemical Name: 1-Benzofuran-4-ylmethanol
• CAS No.: 173470-67-2
• Molecular Formula: C₉H₈O₂
• Molecular Weight: 148.161
• European Community (EC) Number: 828-731-8
• Mol file: 173470-67-2.mol

Synonyms:1-BENZOFURAN-4-YLMETHANOL;(1-Benzofuran-4-yl)methanol;SCHEMBL5357479;AKOS006302967;MB08830;CS-0262852;EN300-840055

Chemical Property of 1-Benzofuran-4-ylmethanol

Chemical Property:

• Boiling Point: 273.251 °C at 760 mmHg
• Flash Point: 119.058 °C
• PSA: 33.37000
• Density: 1.233 g/cm³
• LogP: 1.92510
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 148.052429494
• Heavy Atom Count: 11
• Complexity: 136

Purity/Quality:

99% ^*data from raw suppliers

4-Benzofuranmethanol 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C2C=COC2=C1)CO

Technology Process of 1-Benzofuran-4-ylmethanol

There total 10 articles about 1-Benzofuran-4-ylmethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl benzofuran-4-carboxylate (41019-56-1) → 4-hydroxymethylbenzofurane (173470-67-2)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

Reference yield:

benzofuran-4-carboxylic acid (166599-84-4) → 4-hydroxymethylbenzofurane (173470-67-2)

Guidance literature:

With borane-THF; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield:

benzofuran-4-carboxaldehyde (95333-13-4) → 4-hydroxymethylbenzofurane (173470-67-2)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; methanol; at 0 ℃; for 1h;

DOI:10.1021/acs.jmedchem.6b01473

upstream raw materials:

4-hydroxymethylcoumarilic acid

ethyl 4-methylbenzofuran-2-carboxylate

2,3-dimethylanisole

2-hydroxy-6-methylbenzaldehyde

Downstream raw materials:

4-benzofuran-4-ylmethyl-benzoic acid

4-benzofuran-4-ylmethyl-phenylamine

4-benzofuran-4-ylmethyl-benzaldehyde

Refernces

• 1、 Lingel, Andreas,Sendzik, Martin,Huang, Ying,Shultz, Michael D.,Cantwell, John,Dillon, Michael P.,Fu, Xingnian,Fuller, John,Gabriel, Tobias,Gu, Justin,Jiang, Xiangqing,Li, Ling,Liang, Fang,McKenna, Maureen,Qi, Wei,Rao, Weijun,Sheng, Xijun,Shu, Wei,Sutton, James,Taft, Benjamin,Wang, Long,Zeng, Jue,Zhang, Hailong,Zhang, Maya,Zhao, Kehao,Lindvall, Mika,Bussiere, Dirksen E.. "Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Polycomb Repressive Complex 2 (PRC2) Methyltransferase". supporting information. p. 415 - 427. Retrieved 2017/04/26.
• 2、 Pu,Scripko,Huang. "A facile synthesis of [14C]enadoline [(5R)-(5α,7α,8β)]-N-methyl-N-[7-(1-pyrrolidinyl)-1-oxospiro[4,5] dec-8-yl]-4-benzofuranacetamide". . p. 1183 - 1191. Retrieved 2007/10/03.