Chemical Property of (15R)-18,21-Didehydro-17-demethoxy-18,21-dideoxo-18,21-dihydroxy-15-methoxygeldanamycin
Chemical Property:
- Boiling Point:733.7±60.0 °C (760 mmHg)
- PSA：169.80000
- Density:1.25±0.1 g/cm3 (20 °C, 760 mmHg)
- LogP:4.54160
- Purity/Quality:
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>95% by HPLC *data from raw suppliers
AntibioticTAN420C *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
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Description
TAN 420C is a hydroquinone ansamycin antibiotic originally isolated from Streptomyces. It exhibits antibacterial activity against B. brevis and M. flavus (MICs = 50 and 25 μg/mL, respectively). Additionally, it inhibits proliferation in the lymphocytic leukemia cell lines P388 and KB (ED50s = 0.34 and 3.49 μg/mL, respectively).
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Uses
TAN 420C is a minor analogue of the herbimycin complex, isolated from Streptomyces hygroscopicus. TAN 420C is the hydroquinone of herbimycin C, and is known to exhibit antitumour activity. TAN 420C converts Rous sarcoma virus-infected rat kidney cells into normal cells.
