6-(Hydroxymethyl)piperidin-2-one

Base Information

Chemical Name:6-(Hydroxymethyl)piperidin-2-one
CAS No.:174419-15-9
Molecular Formula:C6H11NO2
Molecular Weight:129.159
Hs Code.:2933790090
European Community (EC) Number:841-136-8
DSSTox Substance ID:DTXSID00561085
Mol file:174419-15-9.mol

Synonyms:6-(HYDROXYMETHYL)PIPERIDIN-2-ONE;174419-15-9;6-HYDROXYMETHYL-PIPERIDIN-2-ONE;2-Piperidinone, 6-(hydroxymethyl)-;6-(HYDROXYMETHYL)-2-PIPERIDINONE;6-hydroxymethyl-2-piperidone;SCHEMBL2999352;DTXSID00561085;VMOQVTPKGUXWKA-UHFFFAOYSA-N;AMY16343;BCP25605;ZGA41915;MFCD11110238;AKOS006307939;AB63547;SB45469;SB47174;racemic 6-hydroxymethyl-piperidin-2-one;AS-61843;CS-0099968;EN300-80073;Y14667;A928367;Z1198313433

Suppliers and Price of 6-(Hydroxymethyl)piperidin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
6-(hydroxymethyl)piperidin-2-one
100mg
$ 130.00

TRC
6-(hydroxymethyl)piperidin-2-one
10mg
$ 45.00

J&W Pharmlab
6-Hydroxymethyl-piperidin-2-one 95%
1g
$ 298.00

Crysdot
6-(Hydroxymethyl)piperidin-2-one 95+%
1g
$ 520.00

Chemenu
6-Hydroxymethyl-piperidin-2-one 95%
1g
$ 486.00

American Custom Chemicals Corporation
6-(HYDROXYMETHYL)PIPERIDIN-2-ONE 95.00%
5MG
$ 499.18

Alichem
6-(Hydroxymethyl)piperidin-2-one
1g
$ 535.60

AK Scientific
6-(Hydroxymethyl)piperidin-2-one
1g
$ 879.00

AccelPharmtech
6-(hydroxymethyl)-2-Piperidinone 97.00%
10G
$ 1910.00

AccelPharmtech
6-(hydroxymethyl)-2-Piperidinone 97.00%
5G
$ 1080.00

Total 15 raw suppliers

Chemical Property of 6-(Hydroxymethyl)piperidin-2-one

Chemical Property:

Boiling Point:346.4±15.0 °C(Predicted)
PKA:14.42±0.10(Predicted)
PSA：52.82000
Density:1.098±0.06 g/cm3(Predicted)
LogP:-0.07670
XLogP3:-0.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:129.078978594
Heavy Atom Count:9
Complexity:114

Purity/Quality:

98%min ^*data from raw suppliers

6-(hydroxymethyl)piperidin-2-one ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(NC(=O)C1)CO

Technology Process of 6-(Hydroxymethyl)piperidin-2-one

There total 4 articles about 6-(Hydroxymethyl)piperidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.6%

: 127274-92-4
ethyl 6-oxopiperidine-2-carboxylate

: 174419-15-9
racemic 6-oxo-2-hydroxymethylpiperidine

Guidance literature:: With lithium borohydride; In tetrahydrofuran; dichloromethane; at 20 ℃; for 1h;

Reference yield: 83.0%

: 1159991-67-9
N-[(mesitylcarbonyl)oxy]hex-5-enamide

: 174419-15-9
racemic 6-oxo-2-hydroxymethylpiperidine

Guidance literature:: N-[(mesitylcarbonyl)oxy]hex-5-enamide; With potassium osmate; In water; acetonitrile; tert-butyl alcohol;

With sodium sulfite; In water; acetonitrile; tert-butyl alcohol;
DOI:10.1021/ol900631y

Reference yield:

: 542-32-5
(R,S)-2-aminoadipic acid

: 174419-15-9
racemic 6-oxo-2-hydroxymethylpiperidine

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / 2.5 h / 0 - 20 °C / Heating / reflux

2: 3 h / 110 °C

3: lithium borohydride / tetrahydrofuran; dichloromethane / 1 h / 20 °C

With lithium borohydride; thionyl chloride; In tetrahydrofuran; dichloromethane;