4-Fluoro-5-(4-methylpiperazin-1-yl)benzene-1,2-diamine

Base Information

Chemical Name:4-Fluoro-5-(4-methylpiperazin-1-yl)benzene-1,2-diamine
CAS No.:174468-55-4
Molecular Formula:C11H17FN4
Molecular Weight:224.281
Hs Code.:2933599090
DSSTox Substance ID:DTXSID70443107
Nikkaji Number:J1.412.041F
Wikidata:Q82260815
Mol file:174468-55-4.mol

Synonyms:174468-55-4;4-fluoro-5-(4-methylpiperazin-1-yl)benzene-1,2-diamine;4-fluoro-5-(4-methyl-piperazin-1-yl)-benzene-1,2-diamine;1,2-Benzenediamine, 4-fluoro-5-(4-methyl-1-piperazinyl)-;SCHEMBL2312002;C11H17FN4;DTXSID70443107;CCAMLNGJMVMMOV-UHFFFAOYSA-N;MFCD12022601;AKOS016005256;SB34270;4-Fluoro-5-(4-methylpiperazino)-o-phenylenediamine;5-fluoro-4-(4-methylpiperazino)-1,2-phenylenediamine;4-fluoro-5-(4-methyl-piperazin-1-yl)benzene-1,2-diamine;4-fluoro-5-(4-methylpiperazin-1-yl)-1,2-phenylenediamine

Suppliers and Price of 4-Fluoro-5-(4-methylpiperazin-1-yl)benzene-1,2-diamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-Fluoro-5-(4-methylpiperazin-1-yl)benzene-1,2-diamine
50mg
$ 45.00

SynQuest Laboratories
4-Fluoro-5-(4-methylpiperazin-1-yl)benzene-1,2-diamine 97%
250 mg
$ 293.00

SynQuest Laboratories
4-Fluoro-5-(4-methylpiperazin-1-yl)benzene-1,2-diamine 97%
1 g
$ 795.00

Matrix Scientific
4-Fluoro-5-(4-methylpiperazin-1-yl)benzene-1,2-diamine 95+%
5g
$ 672.00

Matrix Scientific
4-Fluoro-5-(4-methylpiperazin-1-yl)benzene-1,2-diamine 95+%
1g
$ 227.00

J&W Pharmlab
4-Fluoro-5-(4-methyl-piperazin-1-yl)-benzene-1,2-diamine 97%
100mg
$ 260.00

J&W Pharmlab
4-Fluoro-5-(4-methyl-piperazin-1-yl)-benzene-1,2-diamine 97%
500mg
$ 740.00

J&W Pharmlab
4-Fluoro-5-(4-methyl-piperazin-1-yl)-benzene-1,2-diamine 97%
250mg
$ 420.00

J&W Pharmlab
4-Fluoro-5-(4-methyl-piperazin-1-yl)-benzene-1,2-diamine 97%
25g
$ 18520.00

J&W Pharmlab
4-Fluoro-5-(4-methyl-piperazin-1-yl)-benzene-1,2-diamine 97%
5g
$ 4880.00

Total 8 raw suppliers

Chemical Property of 4-Fluoro-5-(4-methylpiperazin-1-yl)benzene-1,2-diamine

Chemical Property:

PSA：58.52000
LogP:1.90720
XLogP3:0.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:224.14372472
Heavy Atom Count:16
Complexity:230

Purity/Quality:

97% ^*data from raw suppliers

4-Fluoro-5-(4-methylpiperazin-1-yl)benzene-1,2-diamine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1CCN(CC1)C2=C(C=C(C(=C2)N)N)F

Technology Process of 4-Fluoro-5-(4-methylpiperazin-1-yl)benzene-1,2-diamine

There total 9 articles about 4-Fluoro-5-(4-methylpiperazin-1-yl)benzene-1,2-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 82759-10-2
4-fluoro-5-(4-methylpiperazin-1-yl)-2-nitrobenzenamine

: 174468-55-4
1,2-diamino-4-fluoro-5-(4-methyl-1-piperazinyl)benzene

Guidance literature:: With hydrogenchloride; tin(ll) chloride; at 20 ℃; for 2h;
DOI:10.1002/jhet.5570420109

Reference yield:

: 1393681-47-4
5-fluoro-1-amino-4-(4-methylpiperazino)-2-nitrobenzene

: 174468-55-4
1,2-diamino-4-fluoro-5-(4-methyl-1-piperazinyl)benzene

Guidance literature:: With hydrazine; In ethanol; at 30 ℃; Reflux;
DOI:10.1007/s11172-009-0030-6

Reference yield:

: 78056-39-0
4,5-difluoro-2-nitroaniline

: 174468-55-4
1,2-diamino-4-fluoro-5-(4-methyl-1-piperazinyl)benzene

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent

2: 75 percent / NH₂NH₂ / 10 percent Pd/C / ethanol

With hydrazine; palladium on activated charcoal; In ethanol;
DOI:10.1016/S0014-827X(98)00044-5