(1S,2S)-N,N-Bis[2-(diphenylphosphino)benzyl]cyclohexane-1,2-diamine, min. 97%

Base Information

• Chemical Name: (1S,2S)-N,N-Bis[2-(diphenylphosphino)benzyl]cyclohexane-1,2-diamine, min. 97%
• CAS No.: 174677-83-9
• Molecular Formula: C44H44N2P2
• Molecular Weight: 662.794
• Mol file: 174677-83-9.mol

Synonyms:N,N'-bis[2-(diphenylphosphino)benzyl]-1R,2R-diaminocyclo-hexane;(S,S)-N,N'-bis(2-Ph2PC6H4-CH2)cyclohexane-1,2-diamine;N,N'-bis[o-(diphenylphosphino)benzylidene]-1S,2S-diaminocyclohexane;(S,S)-1,2-bis(2-Ph2P-benzylamino)cyclohexane;(1S,2S)-N,N-BIS[2-(DIPHENYLPHOSPHINO)BENZYL]CYCLOHEXANE-1,2-DIAMINE;(S,S)-N,N'-bis[o-diphenylphosphino]benzyl-1,2-diaminocyclohexane;(1S,2S)-N1,N1-Bis(2-(diphenylphosphino)benzyl)cyclohexane-1,2-diamine;N,N'-bis[o-(diphenylphosphino)benzylidene]-(1S,2S)-diaiminocyclohexane;

Chemical Property of (1S,2S)-N,N-Bis[2-(diphenylphosphino)benzyl]cyclohexane-1,2-diamine, min. 97%

Chemical Property:

• Melting Point: 54-56℃
• Boiling Point: 749.8±60.0 °C(Predicted)
• PKA: 9.75±0.40(Predicted)
• PSA: 56.44000
• LogP: 8.17540
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Sensitive.: Air Sensitive
• Water Solubility.: Insoluble in water.

Purity/Quality:

98.5% ^*data from raw suppliers

(1S,2S)-N,N-Bis[2-(diphenylphosphino)benzyl]cyclohexane-1,2-diamine, min. 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: It is employed as a intermediate for pharmaceutical and asymmetirc synthesis.

Technology Process of (1S,2S)-N,N-Bis[2-(diphenylphosphino)benzyl]cyclohexane-1,2-diamine, min. 97%

There total 3 articles about (1S,2S)-N,N-Bis[2-(diphenylphosphino)benzyl]cyclohexane-1,2-diamine, min. 97% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(S,S)-N,N'-bis[o-(diphenylphosphino)benzylidene]-1,2-diiminocyclohexane (174677-82-8) → N,N'-bis[o-(diphenylphosphino)benzylidene]-(1S,2S)-diaiminocyclohexane (174677-83-9)

Guidance literature:

With sodium tetrahydroborate; In ethanol; for 24h; Heating;

DOI:10.1016/S0022-328X(99)00565-3

Reference yield:

(2-formylphenyl)(diphenyl)phosphine (50777-76-9) → N,N'-bis[o-(diphenylphosphino)benzylidene]-(1S,2S)-diaiminocyclohexane (174677-83-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / Na₂SO₄ / CH₂Cl₂ / 24 h

2: 80 percent / NaBH₄ / ethanol / 24 h / Heating

With sodium tetrahydroborate; sodium sulfate; In ethanol; dichloromethane; 1: Condensation / 2: Hydrogenation;

DOI:10.1016/S0022-328X(99)00565-3

Reference yield:

(S,S)-1,2-diaminocyclohexane (21436-03-3) → N,N'-bis[o-(diphenylphosphino)benzylidene]-(1S,2S)-diaiminocyclohexane (174677-83-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / Na₂SO₄ / CH₂Cl₂ / 24 h

2: 80 percent / NaBH₄ / ethanol / 24 h / Heating

With sodium tetrahydroborate; sodium sulfate; In ethanol; dichloromethane; 1: Condensation / 2: Hydrogenation;

DOI:10.1016/S0022-328X(99)00565-3

upstream raw materials:

(S,S)-N,N'-bis[o-(diphenylphosphino)benzylidene]-1,2-diiminocyclohexane

(S,S)-1,2-diaminocyclohexane

(2-formylphenyl)(diphenyl)phosphine

Refernces