1-Piperidinecarboxylic acid, 4-(2-hydroxyphenyl)-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: 1-Piperidinecarboxylic acid, 4-(2-hydroxyphenyl)-, 1,1-dimethylethyl ester
• CAS No.: 174822-86-7
• Molecular Formula: C16H23NO3
• Molecular Weight: 277.364

Synonyms:1-(tert-butyloxycarbonyl)-4-(2-hydroxyphenyl)piperidine;1-Boc-4-(2-hydroxy-phenyl)-piperidine;4-(2-hydroxy-phenyl)-piperidine-1-carboxylic acid tert-butyl ester;

Chemical Property of 1-Piperidinecarboxylic acid, 4-(2-hydroxyphenyl)-, 1,1-dimethylethyl ester

Chemical Property:

• PSA: 49.77000
• LogP: 3.44460

Purity/Quality:

98% ^*data from raw suppliers

tert-Butyl 4-(2-hydroxyphenyl)piperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 1-Piperidinecarboxylic acid, 4-(2-hydroxyphenyl)-, 1,1-dimethylethyl ester

There total 8 articles about 1-Piperidinecarboxylic acid, 4-(2-hydroxyphenyl)-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

di-tert-butyl dicarbonate (24424-99-5) + 4-(2-hydroxyphenyl)-piperidine (161609-76-3) → 4-(2-hydroxy-phenyl)-piperidine-1-carboxylic acid tert-butyl ester (174822-86-7)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1021/acs.jmedchem.0c01058

Reference yield: 85.0%

4-(2-hydroxyphenyl)piperidine hydrobromide (910605-43-5) + di-tert-butyl dicarbonate (24424-99-5) → 4-(2-hydroxy-phenyl)-piperidine-1-carboxylic acid tert-butyl ester (174822-86-7)

Guidance literature:

With sodium hydrogencarbonate; In tetrahydrofuran; water; at 20 ℃;

Reference yield:

C11H14NO(1-)*Na(1+) (1378810-75-3) + di-tert-butyl dicarbonate (24424-99-5) → 4-(2-hydroxy-phenyl)-piperidine-1-carboxylic acid tert-butyl ester (174822-86-7)

Guidance literature:

C₁₁H₁₄NO^(1-)*Na⁽¹⁺⁾; di-tert-butyl dicarbonate; In water; at 20 ℃; for 1h;

With hydrogenchloride; In water;

upstream raw materials:

C₁₁H₁₄NO^(1-)*Na⁽¹⁺⁾

di-tert-butyl dicarbonate

4-(2-hydroxyphenyl)piperidine hydrobromide

4-(2-hydroxyphenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

Downstream raw materials:

C₂₂H₃₄N₂O₃

C₁₈H₂₆BrNO₃

C₂₁H₂₉N₃O₃

C₁₈H₂₀FNO

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