1-Bromo-3-chloro-2-methoxybenzene

Base Information

• Chemical Name: 1-Bromo-3-chloro-2-methoxybenzene
• CAS No.: 174913-10-1
• Molecular Formula: C7H6BrClO
• Molecular Weight: 221.481
• Hs Code.: 2909309090
• Mol file: 174913-10-1.mol

Synonyms:1-Bromo-3-chloro-2-methoxybenzene;

Chemical Property of 1-Bromo-3-chloro-2-methoxybenzene

Chemical Property:

• Boiling Point: 235.8±20.0 °C(Predicted)
• PSA: 9.23000
• Density: 1.564±0.06 g/cm3(Predicted)
• LogP: 3.11110
• Storage Temp.: Room temperature.

Purity/Quality:

98% ^*data from raw suppliers

2-Bromo-6-chloroanisole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Bromo-3-chloro-2-methoxybenzene

There total 1 articles about 1-Bromo-3-chloro-2-methoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-chloro-4-iodo-2-methoxyaniline + 3-chloro-2-methoxyaniline (51114-68-2) → 1-bromo-2-methoxy-3-chlorobenzene (174913-10-1) + 1-bromo-3-chloro-4-iodo-2-methoxybenzene

Guidance literature:

3-chloro-4-iodo-2-methoxyaniline; 3-chloro-2-methoxyaniline; With hydrogen bromide; sodium nitrite; In 1,4-dioxane; water; at 0 ℃;

With copper(I) bromide; In 1,4-dioxane; water; at 0 - 20 ℃; for 0.5h;

Reference yield: 91.0%

1-bromo-2-methoxy-3-chlorobenzene (174913-10-1) + Triisopropyl borate (5419-55-6) → (3-chloro-2-methoxyphenyl)boronic acid (179898-50-1)

Guidance literature:

1-bromo-3-chloro-2-methoxybenzene; With tert.-butyl lithium; In tetrahydrofuran; at -78 - 20 ℃; for 1h;

Triisopropyl borate; In tetrahydrofuran; for 3h;

With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; for 1.5h;

Reference yield: 91.0%

1-bromo-2-methoxy-3-chlorobenzene (174913-10-1) + Triisopropyl borate (5419-55-6) + water (7732-18-5) → (3-chloro-2-methoxyphenyl)boronic acid (179898-50-1)

Guidance literature:

1-bromo-3-chloro-2-methoxybenzene; With tert.-butyl lithium; In tetrahydrofuran; at -78 ℃; for 1h;

Triisopropyl borate; In tetrahydrofuran; at 20 ℃; for 3h;

water; With hydrogenchloride; In tetrahydrofuran; at 20 ℃; for 1.5h;

upstream raw materials:

3-chloro-2-methoxyaniline

Downstream raw materials:

(3-chloro-2-methoxyphenyl)boronic acid

methyl (3'-chloro-2'-methoxy-4-nitro-2-biphenylcarboxylate)

3-chloro-2-methoxy-1-methylbenzene

Refernces