2-Isopropylquinoline

Base Information

• Chemical Name: 2-Isopropylquinoline
• CAS No.: 17507-24-3
• Molecular Formula: C12H13N
• Molecular Weight: 171.242
• Hs Code.: 2933499090
• Mol file: 17507-24-3.mol

Synonyms:Quinoline,2-isopropyl;2-Isopropylquinoline;

Chemical Property of 2-Isopropylquinoline

Chemical Property:

• PSA: 12.89000
• LogP: 3.35820

Purity/Quality:

95+% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Isopropylquinoline

There total 3 articles about 2-Isopropylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

2-Aminobenzyl alcohol (5344-90-1) + 3-methyl-2-butanol (598-75-4) → 2-(2-quinolyl)propane (17507-24-3) + 2-isopropyl-1,2,3,4-tetrahydroquinoline (53627-32-0,608525-30-0)

Guidance literature:

3-methyl-2-butanol; With 2C₂₁H₂₂MnNO₃P⁽¹⁺⁾*Br^(1-)*0.5Br₄Mn^(2-); potassium hydride; at -5 ℃; for 0.0833333h; Inert atmosphere; Glovebox; Sealed tube;

2-Aminobenzyl alcohol; With potassium hydroxide; In 1,2-dimethoxyethane; at 120 ℃; for 24h; Inert atmosphere; Glovebox; Sealed tube;

DOI:10.1021/acs.orglett.0c02905

Reference yield: 27.0%

2,3-Dimethyl-2-butene (563-79-1) + Quinoline-2-thione (2637-37-8,4481-48-5) → 2-(2-quinolyl)propane (17507-24-3) + thioacetone (4756-05-2) + 2-(2-Mercapto-1,1,2-trimethylpropyl)quinoline (111181-07-8) + Bis<1,1,2,2-tetramethyl-2-(2-quinolyl)ethyl>disulfide (111181-08-9)

Guidance literature:

In acetonitrile; for 3h; Further byproducts given; Irradiation;

DOI:10.1246/cl.1987.273

Reference yield:

2-isopropyl-1,2,3,4-tetrahydroquinoline (53627-32-0,608525-30-0) → 2-(2-quinolyl)propane (17507-24-3) + (S)-2-isopropyl-1,2,3,4-tetrahydroquinoline (608525-30-0)

Guidance literature:

With suspended cells of Pseudomonas monteilii ZMU-T₀₁; In aq. phosphate buffer; at 30 ℃; for 24h; pH=7; enantioselective reaction; Resolution of racemate; Green chemistry; Enzymatic reaction;

DOI:10.1016/j.tetlet.2016.04.066

upstream raw materials:

2,3-Dimethyl-2-butene

Quinoline-2-thione

2-isopropyl-1,2,3,4-tetrahydroquinoline

2-Aminobenzyl alcohol

Downstream raw materials:

1-quinolin-2-yl-ethanone

(S)-2-isopropyl-1,2,3,4-tetrahydroquinoline

(R)-2-isopropyl-1,2,3,4-tetrahydroquinoline

2-isopropyl-5,6,7,8-tetrahydroquinoline

Refernces

• 1、 Qin, Lei,Zheng, Daijun,Cui, Baodong,Wan, Nanwei,Zhou, Xiaojian,Chen, Yongzheng. "Bio-mediated oxidative resolution of racemic 2-substituted 1,2,3,4-tetrahydroquinolines". supporting information. p. 2403 - 2405. Retrieved 2016/05/19.